Оценка Функционального Состояния Щитовидной Железы У Беременных Женщин В Регионе Легкого Йодного Дефицита

Макарова, О. Б.; России, Фгбоу Во Тюменский Гму Минздрава; Суплотова, Л. А.

doi:10.14341/conf22-25.09.21-262

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“…Следует отметить, что йодная недостаточность во время беременности может стать причиной развития аномалии у плода [6]. Хотя гипотироксинемия у беременных является распространенным явлением и связана со здоровьем потомства, современные акушерские руководства не рекомендуют проводить регулярный скрининг щитовидной железы у беременных женщин [7]. При этом имеются ограниченные данные относительно того, может ли умеренная дисфункция щитовидной железы у плода / младенцев или даже изменение в пределах нормального диапазона уровней влиять на дальнейшее развитие детей.…”

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Indicator of thyroid hormones in newborns from mothers with diffuse-endemic goiter

Makhkamova

Turdieva

2023

Medicinskij sovet

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Introduction. Pathologies of thyroid dysfunction associated with iodine deficiency remain one of the urgent problems throughout the world and are mainly associated with natural iodine deficiency in places where about 30% of the world’s population lives.Objective. Study of the dynamics of thyroid hormones in infants born from mothers with diffuse endemic goiter.Materials and methods. A retrospective study of 68 infants from mothers with diffuse endemic goiter (DEG) was carried out. Research methods included: analysis of anamnestic data, palpation, and ultrasound in mothers, with a study of the level of thyroid hormone in newborns and parturient women.Results. Infants from mothers with DEG have characteristic changes in the level of thyroid hormones in the blood, in particular, in the cord blood, the level of thyroid-stimulating hormone (TSH) is 22.4% higher than in the control group (p < 0.05). The difference between free triiodothyronine (T3) and thyroxine (T4) is on average lower by 8.6% and 4.3%, respectively, (p < 0.05 and p < 0.1). On the 3rd day of life, these fluctuations persist, and the level of TSH in the peripheral blood exceeded up to 20.9%, but there were no pronounced clinical signs of congenital pathology associated with the thyroid gland. At the same time, in the first months of life in infants, there is a lag in weight gain by an average of 9.6% about practically healthy newborns.Conclusion. In infants born to mothers with DEG, there is an increase in the umbilical blood level of TSH up to 22.4% about practically healthy newborns, with a simultaneous decrease in T4 to 4.3%, T3 to 8.6%, without pronounced clinical signs of congenital pathology. In these children, in the first months of life, there is a lag in physiological weight gain of up to 9.6%, which should be taken into account when managing children in an outpatient setting.

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Section: Introductionunclassified

Indicator of thyroid hormones in newborns from mothers with diffuse-endemic goiter

Makhkamova

Turdieva

2023

Medicinskij sovet

View full text Add to dashboard Cite

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Оценка Функционального Состояния Щитовидной Железы У Беременных Женщин В Регионе Легкого Йодного Дефицита

Cited by 1 publication

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Indicator of thyroid hormones in newborns from mothers with diffuse-endemic goiter

Indicator of thyroid hormones in newborns from mothers with diffuse-endemic goiter

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