Сравнительный Анализ Влияния Витамина С И Оротата Калия На Морфологическую Картину При Имплантации Герниоимплантата В Эксперименте

Лазаренко, В. А.; Ivanov, S; Ivanov, I.; Иванов, Александр Викторович; Цуканов, Андрей Викторович; Тарабрин, Денис Владимирович; Кулабухов, Алексей Сергеевич

doi:10.21626/vestnik/2019-1/04

Cited by 5 publications

(3 citation statements)

References 2 publications

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“…This drug belongs to several pharmacological groups: antihypoxants and antioxidants, angioprotectors and microcirculation correctors, regenerants and reparants. Solcoseryl contains a large number of active substances that supply cells with high-energy phosphates by improving glucose transport, aerobic glycolysis and oxidative phosphorylation, reduce degenerative processes in tissues and improve reparative ones, and therefore can correct various phases of wound repair and affect collagen formation (Lazarenko et al 2016;Ob'edkov et al 2019;Ivanov et al 2020;Register of Medicines of Russia 2021a, b). The drug has a systemic effect when injected intravenously or intramuscularly and can be used topically as ointment or gel, the dosage depends on a nosological form of the disease.…”

Section: Introductionmentioning

confidence: 99%

“…Vitamin C affects the synthesis of DNA, intracellular collagen, lipids and proteins, oxidative phosphorylation, carbohydrate metabolism, has antioxidant properties due to the regulation of H+ ion transport, regulates immunological reactions (activates synthesis of antibodies, C3 component of the complement, interferon), promotes phagocytosis, increases body's resistance to infections, has anti-inflammatory and anti-allergic effects, inhibits release and accelerates the degradation of histamine, inhibits the formation of prostaglandins and other inflammatory mediators and anaphylaxis, reduces the need for vitamins B 1 , B 2 , A, E, folic acid, and pantothenic acid. Such properties of ascorbic acid allow it to influence the process of collagen formation, accelerating the process of wound healing, shortening the exudative phase of inflammation, stimulating the maturation of connective tissue, normalizing the ratio of collagen types I and III and accelerating the formation of a postoperative scar (Lazarenko et al 2019;Register of Medicines of Russia 2021a, b). The maximum absorption of the drug (70%) is achieved at a dosage of 200 mg. Vitamin C can be administered orally, intramuscularly, intravenously, intravaginally, the dosage depending on the nature and course of the disease.…”

Section: Introductionmentioning

confidence: 99%

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Studying the influence of Solcoseryl drug and vitamin C on the inflammatory reaction and proliferation of fibroblastic cells in the filed of polypropylene endoprosthesis implantation

Лазаренко¹,

Ivanov²,

Панкрушева³

et al. 2021

RRP

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Introduction: Applying a coating on hernia endoprosthesis prevents recurrent anterior abdominal wall hernias, reduces inflammatory response and stimulates reparative processes in the area of its implantation. The aim of investigation was to study the effect of Solcoseryl and Vitamin C in a collagen-stimulating coating of hernioendoprosthesis on a morphological picture in anterior abdominal wall plastic surgery. Materials and methods: The study was performed on 180 laboratory mice divided into three groups of 60 animals each: the first group animals were implanted with polypropylene endoprostheses without a collagen-stimulating coating, the second group animals – polypropylene endoprostheses with a collagen-stimulating coating with Vitamin C, and the third group animals – polypropylene endoprostheses with a collagen-stimulating coating with Solcoseryl. The laboratory animals were withdrawn from the experiment on the 10th, 30th, 60th, and 90th days. The excised sections of the abdominal wall were stained with G+E to determine the nature of inflammation and the number of cell elements. Results and discussion: When using endoprostheses with a collagen-stimulating coating, the stages of inflammatory process proceeded more quickly, which was confirmed by a reliable (р ≤ 0.05) decrease in the number of neutrophils, macrophages and lymphocytes at all stages of the study. By the 90th day of the experiment, the number of fibroblasts in the control group was by 22.64% less than in the study groups with a coating. Conclusion: A cytological and histological analysis in the control group determined a consistent decrease in an exudative phase of inflammatory reaction. When using endoprosthesis with coatings, its acceleration and lower intensity was noted throughout the study. In the group with Solcoseryl, the formation of a dense connective capsule around the endoprosthesis indicates its quality and better adaptation of the endoprosthesis in body tissues.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Studying the influence of Solcoseryl drug and vitamin C on the inflammatory reaction and proliferation of fibroblastic cells in the filed of polypropylene endoprosthesis implantation

Лазаренко¹,

Ivanov²,

Панкрушева³

et al. 2021

RRP

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“…Тем самым дисбаланс между коллагеном I и III типов приводит к появлению первичных или рецидивирующих грыж передней брюшной стенки [1,2].…”

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Use of Collagen-Stimulating Coatings for Herniaimplants: Comparison of Morphological Characteristics of Tissue in the Implantation Area

Ponomareva¹,

Tsukanov²,

Ivanov³

et al. 2023

СПНО (MPSE)

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It is necessary to pay attention to herniaimplants with a collagen-stimulating coating during herniaplasty of the anterior abdominal wall in order to achieve adequate biocompatibility in the area implantation. The purpose of the work is to evaluate the response of tissues to implantable polypropylene herniaimplants with and without collagen-stimulating coating. In the study 75 Wistar rats were divided into 3 groups: the first group was implanted with a polypropylene herniaimplant without coating, the second groupa polypropylene herniaimplant with a rutine coating, the third group -a polypropylene herniaimplant with coating a rutine + ascorbic acid. On days 7, 30 and 90, histological sections of the biomaterial of laboratory animals were examined using light microscopy after staining with hematoxylin and eosin according to the method of Van Gieson and Mallory. On the 7 day, in the area of implantation of the polypropylene herniaimplant with coated rutin + ascorbic acid, a significant (p≤0, 05) increase in the rate of fibroblast series cell proliferation was observed compared to polypropylene herniaimplants without coating and with rutin coating. However, on day 90, a statistically significant (p≤0, 05) decrease in the number of fibrocytes was observed in the group with a rutine implant coating compared to the control group and the group of a polypropylene herniaimplant with coated rutin + ascorbic acid. The herniaimplant with coated rutin + ascorbic acid integrated better with the surrounding tissues, which was expressed in the early predominance of fibroblast series cells, which contributed to the synthesis of collagen.

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Morphological Changes in the Somatosensory Cortex of Guinea Pigs Following Simulation of the Abdominal Surgery Wound

Ishunina

2021

Žurnal anatomii i gistopatologii

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The aim of research was to study the effect of the abdominal wall injuries and ascorbic acid (AA) on morphometric parameters of the somatosensory cortex.Material and methods. The density of the arrangement of neurons, sizes of nuclei and perikaryons of neurons, density and area of blood vessels in the somatosensory cortex were detected in guinea pigs after simulation of the abdominal wall injury. The process was accompanied by the parenteral administration of AA.Results. Simulation of the abdominal wall injury in guinea pigs resulted in a decreased thickness of the somatosensory cortex and a decreased density of neurons arrangement (on average by 32-37%). In 7 days after the operation, the exposed animals demonstrated a decreased density of blood vessels by 14–18%, the size of blood vessels also decreased by 27–46%; the fact evidencing a deterioration in the blood supply to the somatosensory cortex in the postoperative period. The effect of AA was mainly manifested in the increased size of the nuclei and perikaryons of neurons (by 20–40%); this evidencing activation of their metabolic activity. The most significant changes in the studied parameters were observed in the outer granular and, to a lesser extent, in the pyramidal and inner granular cytoarchitectonic layers.Conclusion. Experimental abdominal surgical interventions resulted in a decreased size and density of blood vessels in the somatosensory cortex. The results obtained can be used to develop methods of postoperative rehabilitation with the inclusion of drugs that improve blood supply and metabolism of the brain neurons. AA potentiates some of the effects of surgery on the somatosensory cortex; currently, there are no sufficient data to recommend it as a neuroprotective agent in the postoperative period.

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Сравнительный Анализ Влияния Витамина С И Оротата Калия На Морфологическую Картину При Имплантации Герниоимплантата В Эксперименте

Cited by 5 publications

References 2 publications

Studying the influence of Solcoseryl drug and vitamin C on the inflammatory reaction and proliferation of fibroblastic cells in the filed of polypropylene endoprosthesis implantation

Studying the influence of Solcoseryl drug and vitamin C on the inflammatory reaction and proliferation of fibroblastic cells in the filed of polypropylene endoprosthesis implantation

Use of Collagen-Stimulating Coatings for Herniaimplants: Comparison of Morphological Characteristics of Tissue in the Implantation Area

Morphological Changes in the Somatosensory Cortex of Guinea Pigs Following Simulation of the Abdominal Surgery Wound

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