Цукровий Діабет Й Екзокринна Недостатність Підшлункової Залози (Огляд Літератури)

Daminova, L.T.; Muminova, S.U.

doi:10.22141/2224-0721.14.1.2018.127093

Cited by 5 publications

(2 citation statements)

References 9 publications

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“…According to official statistics, the rate of prevalence of diseases associated with damage to the pancreas will significantly exceed the rate of growth of the general prevalence of diseases of the digestive organs [1]. The pancreas plays a leading role in the activity of the body as a whole, and therefore when it is damaged (intoxication, autoimmune diseases) due to endo-and exocrine dysfunction, systemic metabolic disorders occur [2,3,4,5].…”

Section: Introductionmentioning

confidence: 99%

“…Chronic stress has been shown in many studies to increase levels of corticosterone, blood glucose, and decrease insulin levels, which is associated with pancreatic β-cell damage, metabolic shifts, and abnormalities in the prenatal development of offspring that are observed up to the postpubertal period of life [3,5]. Currently, the literature is actively considering the impact of vital macro-and microelements on the functioning of the body of adults [7] and children [8,9].…”

Section: Introductionmentioning

confidence: 99%

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The Effect of Chronic Immobilization Stress on the Content of Micro- And Macroelements in the Pancreas and Blood Serum of Rats and Their Newborn Offspring

Павлова,

Сіренко

2023

SWJ

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The Effect of Chronic Immobilization Stress on the Content of Micro- And Macroelements in the Pancreas and Blood Serum of Rats and Their Newborn Offspring

Павлова,

Сіренко

2023

SWJ

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Frequency of hyperglycemia and polymorphism of TNF and TP53 genes in patients with acute pancreatitis, chronic pancreatitis, pancreatic cancer

et al. 2021

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BACKGROUND: «The vicious circle» of associations of diabetes mellitus (DM) with pancreatic pathology, when pancreatic diseases can initiate DM, and type 2 DM — cause functional and organic pancreatic pathology, determines the search for possible associations. Some studies have established a relationship between TNF or TP53 polymorphisms with DM or with pancreatic diseases.AIMS: to determine and compare fasting plasma glucose and the frequency of hyperglycemia in patients with acute pancreatitis (APp), chronic pancreatitis (CPp), pancreatic cancer (PCp) depending on gender, etiology or stage of the disease, polymorphism -308G/A TNF gene in all patients, and polymorphism 72Arg/Pro gene TP53 in PCp..MATERIALS AND METHODS: At the observational multicenter clinical cross-sectional uncontrolled case-study 44 APp, 97 CPp and 45 PCp were examined; the groups were comparable by sex/age. Informed consent form for participate in the study was obtained from all patients. The main outcome of the study: frequency of hyperglycemia in APp, CPp, PCp, considering the polymorphism TNF and TP53 genes. RESULTS: The lowest age-standardized fasting plasma glucose (FPG) was found in CPp (6,2±0,2 mmol/l) than in APp (6,7±0,2 mmol/l, p=0,041). In PCp (6,6±0,2 mmol/l), the average levels of FPG did not differ substantially when compared with APp (p=0,749) or CPp (p=0,092). In APp, the norm of GP was detected less frequently (31,8%) than in CPp (54,6%, χ2 =6,3, p=0,012), and the frequency of the norm of GP in PCp (48,9%) did not differ with that in APp or CPp. The frequency of FPG≥6,1<7,0 mmol/l did not differ in APp (20,5%), CPp (9,3%) or PCp (17,8%). The frequency of FGP≥7.0 mmol/l did not differ in APp CPp and PCp: 47,7, 36,1, 33,3%. Logistic regression analysis revealed a tendency for an increased chance of having stage 3–4 PC with FPG≥7,0 mmol/l (Exp (B)=3,205 95%CI 0,866–11,855, p=0,081) in PCp, but not in patients with pancreatic necrosis or “definite» СP.The frequencies of G/G (71,4, 74,7, 76,2%), G/A (26,2, 24,1, 23,8%) of TNF genotypes did not differ in APp, CPp or PCp, p>0,05. In PCp genotypes Arg/Arg, Arg/Pro, Pro/Pro polymorphism gene 72Arg/Pro TP53 in 2,4, 35,7, 61,9% of cases. No associations of GP≥7,0 mmol/l with TNF polymorphism in APp, CPp, PCp and with TP53 polymorphism in PCp were obtained.CONCLUSIONS: The frequency of FGP≥7,0 mmol/l did not differ for various pancreatic disease and was not associated with the risk of pancreatic necrosis and “defined” CP. The -308G/A polymorphism TNF gene did not differ in APp, CPp or PCp and was not associated with impaired carbohydrate metabolism. The 72Arg/Pro polymorphism TP53 gene in PCp was not associated with impaired carbohydrate metabolism.

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The importance of vaspin in external and internal secretory activity of the pancreas

Pylov¹

2021

Shidnoevr. z. vnutr. simejnoi med.

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To analyze the data of the scientific literature on the importance of vaspin as a pathogenetic link in the development of insufficiency of exocrine function of the pancreas in type 2 diabetes patients in combination with chronic pancreatitis and. Literary sources were searched in the scientometric databases Scopus and Web of Science, using the electronic search system Pubmed, mainly for the last 5 years. The search terms were: “type 2 diabetes”, “chronic pancreatitis”, “pancreas”, “exocrine function of the pancreas”, “obesity”, “vaspin”, “type 2 diabetes mellitus”, “pancreas », « obesity »,« vaspin ». An increase in the incidence of chronic pancreatitis and type 2 diabetes mellitus, as well as its severe complications, which are often associated with insulin resistance, hyperinsulinemia. Comorbid conditions can contribute to dysfunction of the pancreas. The existing relationships between vaspin level, insulin resistance, type 2 diabetes mellitus and chronic pancreatitis are not well understood. Many authors see the value and information content of vaspin as a biomarker for diagnosing these diseases and predicting treatment outcomes. The study of the effects and mechanisms of action of vaspin is the basis for determining new targets for the treatment of diabetes mellitus and chronic pancreatitis, both in isolated pathology and in combination.

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Цукровий Діабет Й Екзокринна Недостатність Підшлункової Залози (Огляд Літератури)

Cited by 5 publications

References 9 publications

The Effect of Chronic Immobilization Stress on the Content of Micro- And Macroelements in the Pancreas and Blood Serum of Rats and Their Newborn Offspring

The Effect of Chronic Immobilization Stress on the Content of Micro- And Macroelements in the Pancreas and Blood Serum of Rats and Their Newborn Offspring

Frequency of hyperglycemia and polymorphism of TNF and TP53 genes in patients with acute pancreatitis, chronic pancreatitis, pancreatic cancer

The importance of vaspin in external and internal secretory activity of the pancreas

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