التأثيرات المحتملة للأوراق الکاري والجوز على الفئران المصابة بالسکر المستحث بالألوکسان

Abstract

Egypt is among the world's top 10 countries in the number of patients with diabetes mellitus (DM). Medicinal plants are used to treat diabetes to overcome hypoglycemic medications' cost and unwanted side effects. The current study investigated the potential effects of curry and walnut leaves powders (CLP and WLP) and their methanolic extracts (CLEx and WLEx) on diabetic rats. Sixty male albino rats weighing (150±10g) were divided into two main groups. The first main group (group 1=6 rats): as control (-ve) fed on the basal diet BD. The second main group (diabetic rats, 54 rats): was injected with alloxan to induce DM and divided into nine subgroups, six rats for each as follows: group (2): as control (+ve) fed on BD, groups (3-6): fed on BD containing (5.0 and 7.0 %, w/w) of CLP and WLP; and groups (7-10): fed on BD and orally administered with (200 and 400 mg/kg/d) of CLEx and WLEx, for 42 days respectively. Results showed that alloxan induced a significant (P≤0.05) decrease in insulin, HDL-c, Superoxide dismutase (SOD), Glutathione peroxidase (GPX), and Catalase (CAT) levels; and significantly increased blood glucose level, liver and kidney functions parameters, lipid profile and malondialdehyde content (MDA). Treatment of diabetic rats with CLP, WLP, CLEx and WLEx at the tested concentrations improved all indicated markers. In conclusion, these findings may provide a basis for utilizing curry and walnut leaves, or foods fortified with them, for the prevention/treatment of DM instead of/beside synthetic medications that may have adverse effects.