Egypt is among the world's top 10 countries in the number of patients with diabetes mellitus (DM). Medicinal plants are used to treat diabetes to overcome hypoglycemic medications' cost and unwanted side effects. The current study investigated the potential effects of curry and walnut leaves powders (CLP and WLP) and their methanolic extracts (CLEx and WLEx) on diabetic rats. Sixty male albino rats weighing (150±10g) were divided into two main groups. The first main group (group 1=6 rats): as control (-ve) fed on the basal diet BD. The second main group (diabetic rats, 54 rats): was injected with alloxan to induce DM and divided into nine subgroups, six rats for each as follows: group (2): as control (+ve) fed on BD, groups (3-6): fed on BD containing (5.0 and 7.0 %, w/w) of CLP and WLP; and groups (7-10): fed on BD and orally administered with (200 and 400 mg/kg/d) of CLEx and WLEx, for 42 days respectively. Results showed that alloxan induced a significant (P≤0.05) decrease in insulin, HDL-c, Superoxide dismutase (SOD), Glutathione peroxidase (GPX), and Catalase (CAT) levels; and significantly increased blood glucose level, liver and kidney functions parameters, lipid profile and malondialdehyde content (MDA). Treatment of diabetic rats with CLP, WLP, CLEx and WLEx at the tested concentrations improved all indicated markers. In conclusion, these findings may provide a basis for utilizing curry and walnut leaves, or foods fortified with them, for the prevention/treatment of DM instead of/beside synthetic medications that may have adverse effects.
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This study aimed to investigate the effect of two levels of olive oil, olive leave and their mixture on rats suffering from acute liver disease. In addition to determine the chemical composition and phenolic compounds. Forty eight male albino rats (Sprague Dawley) used in this study. Rats divided into two main groups. First main group (6 rats) was fed on basal diet, as negative control. The second main group (42 rats) fed on basal diet and were treated with CCL4 in paraffin oil (50% v/v 4ml/kg) by a single dose subcutaneous injection to induce acute damage in the liver. After injection, AST, ALT and ALP enzymes activity were determined in the first and second main groups to insure the induction. Then the rats in the second main group were divided into seven subgroups (n = 6) according to the following: Subgroup 1: fed on normal basal diet, this group used as a (positive control group). Subgroup 2&3: fed on diet containing (3.5% and 7%) olive oil, respectively. Subgroup 4&5: fed on diet containing (3.5% and 7%) olive leave , respectively. Subgroup 6: fed on basal diet containing (3.5% olive oil and 3.5% olive leave). Subgroup 7: fed on basal diet containing (7% olive oil and 7% olive leave). The results revealed that, injected rats with CCl4 induced decrease in feed intake, BWG% and HDLc, while organs weight / body weight%, serum (cholesterol, triglycerides, LDL-c, VLDL-c, AST, ALT and ALP) increased significantly, as compared to non-injected rats (control negative group). Treating acute liver disease groups with the two levels from olive oil, olive leave and their combination improved all parameters, especially the groups which were treated with (7% olive oil and 7% olive leave) and (3.5% olive oil and 3.5% olive leave). From these results, it could be concluded that, olive oil, olive leave and the combination from them improved liver enzymes and the complication resulting from CCl4.
The aim of this study was to evaluate effect of parsley on weight loss and antioxidant enzymes in overweight and obese women subjects. A number of 150 women subjects were classified as follow: group (1) 30 normal volunteers women with BMI<25 Kg/m 2 was considered as a control group, group (2) 30 overweight women with BMI between 25-30 Kg/m 2 eating one cup/ day parsley in addition their weight reduction diet, group (3) 30 obese women with BMI>30 Kg/m 2 eating one cup/day parsley in addition their weight reduction diet, group (4) 30 overweight women with BMI between 25-30 Kg/m 2 eating only their weight reduction diet, group (5) 30 obese women with BMI>30 Kg/m 2 eating only their weight reduction diet. The weight reduction diet is containing the same types and quantities for all participants in groups 2, 3, 4 and 5 with exchange during the week days along the study period. Age (35-60 years) with no prior history of chronic diseases was selected from outpatient clinics in Assiut University Hospitals after their agreement for the participation in the study. Information on age, weight, height was collected. Antioxidant enzymes including superoxide dismutase (SOD), glutathione reductase (GR), glutathione peroxidase (GPX) and catalase (CAT) were assessed in the groups at the beginning of the study and after 2 months of intervention. The investigation was
Daily intake of functional foods containing adequate amount of dietary fiber within daily diet has many health benefits. Corncob silk is a byproduct of corn processing, is a rich source of dietary fiber and bioactive compounds. The present study aims to investigate the effect of using corncob silk powder (CSP) as a functional ingredient in bakery products. Also, the influence of corncob silk extract (CSE) on cancer cell proliferation was investigated. Four different concentrations (5, 10, 15 and 20% as a substitution of wheat flour) of CSP were used. The chemical composition results showed that corncob silk contains 10.2% moisture, 16.65% total protein, 0.86% crude fat, 5.25% ash and 39.25% total dietary fiber. Also, increasing the level of replacement from 5 % to 20% of CSE induced an improvement in total protein, crude fat, crude fiber and ash content in all cake samples. Cake blends which prepared by substitution of wheat flour (72%) with 5, 10, 15 and 20% CSP showed a significant (p≤0.05) increase in the cake weights and volumes, while, specific volume was decreased significantly. Texture properties of cake were affected, the hardness, cohesiveness and chewiness values were in the range of 19.07-27.63, 0.57-0.42 and 75.40-95.70%, respectively. Sensory evaluation results indicated that replacement of wheat flour with 5 and 10% CSP in the cake mixture didn't impact the general acceptability. Additionally, total scores of sensory evaluation showed that all cake samples recorded 75% higher than the control samples. Inhibitory concentration (IC50) of corncob silk extraction cancer cell proliferation from colon was 18.5 µg/ml. In conclusion, these findings confirm that by-products corncob silk has great potential in food applications especially in development of functional foods.
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