Present study was carried out to determine the phytochemical constituents and activities of aqueous ethanolic leaf extract from Tapinanthus dodoneifolius grown on Tamarindus indica tree. Results obtained for phytochemical revealed the presence of flavonoids, tannins, saponins, glycosides and alkaloids. Antiulcer activity o ethanolic leaf extract from Tapinanthus dodoneifolius grown on Tamarindus indica tree was tested on wistar rats' stomach which was compared with standard antiulcer drug Omeparazole. Oral administration of aqueous ethanolic leaf extract from Tapin dodoneifolius (500-1500mg/cm 3 ) to Aspirin induced ulcerated wistar rats for one week reduced the incident of ulceration in a dose dependent manner. Acute toxicity study of the extract did not manifest any toxicological signs in rats. Thus the plant relatively safe and it has potential antiulcer activity.