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Objective Steroid-responsive meningitis arteritis (SRMA) is one of the most common inflammatory diseases of the central nervous system in dogs. The present study examined breed and sex predisposition factors based on the population of dogs in Germany as well as epidemiological and clinical factors regarding the relapse rate of SRMA. Material and methods Data of 153 dogs with SRMA (SRMA) were analysed retrospectively in this multicentre study. It was investigated whether some dog breeds that suffer from SRMA were disproportionately more often (n ≥ 5) represented when compared to the total population of dogs in Germany. Furthermore it was examined which sex is affected more often. Data provided by “Verband für das deutsche Hundewesen“ (VDH) and „Tasso e. V.“ was used as reference data of the total population. The following factors were investigated with regard to the occurrence of one or more relapses: signalment; body weight; age at first presentation; time period between last vaccination and onset of clinical signs; clinical signs and timepoint of the first SRMA manifestation; results of cerebrospinal fluid (CSF) analysis at first presentation (nucleated cell count and differentiation, protein concentration); immunglobulin A and C-reactive protein (CRP) concentrations in serum and CSF; immunosuppressive medication; follow-up data including response to therapy, occurrence of relapses and mortality including reasons, i. e. due to the disease, therapy or euthanasia. Results The breed had a statistically significant influence on the development of SRMA (p < 0.05). Beagles and Boxers were affected more often by SRMA than other breeds in relation to the total population in Germany. Relapses occurred in 29.4 % of the 153 dogs of this study. In contrast to the development of SRMA, in which male dogs have a significantly increased risk of developing SRMA (p < 0.05), female dogs are more likely to relapse (p = 0.02). Patients on prednisolone monotherapy had fewer relapses than those with prednisolone and azathioprine in combination (p < 0.05). Younger age (p = 0.071) und lower CRP concentrations (p = 0.081) at first presentation were tentatively associated with a higher incidence of relapses. Conclusion The determined breed and sex predispositions support the diagnosis of SRMA arteritis and confirm previous observations. This study allows a more accurate explanation to owners about the risk of relapse.

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ZusammenfassungFragestellung: Die Publikation der schwedischen 5-Jahres-Daten nach TVT-Implantation zeigte neben hervorragenden Erfolgsraten kaum Nebenwirkungen im Sinne von Drangproblemen oder obstruktiven Miktionsproblemen unterschiedlichen Ausmaûes. In unserem fast 800 Patientinnen umfassenden Kollektiv traten solche Probleme sehr wohl auf. Aus dem Kollektiv der mit einer Banddurchtrennung nach TVT behandelten Patientinnen heraus wollen wir versuchen, den Hintergrund dieser Nebenwirkung etwas zu beleuchten und vielleicht eine Erklärung für die Diskrepanz zu den schwedischen Daten zu finden. Methodik: Die in unserer Klinik durchgeführten 45 TVT-Durchtrennungen wurden hinsichtlich der zur Verfügung stehenden erfassten Befunde und Daten so vollständig wie möglich ausgewertet. Vorliegende Urodynamiken und Perinealsonographien präund postoperativ sowie der klinische Befund, aber auch präund postoperative Anamnese und Miktionsprotokolle konnten dabei zur Analyse herangezogen werden. Ergebnisse: Neben der Operationstechnik, die für eine inkorrekte Lage verantwortlich sein dürfte, spielen Beckenbodenmuskelfunktion, vaginale subvesikale und suburethrale Mobilität sowie das präoperativ von der Patientin geklagte Beschwerdebild eine wesentliche Rolle. Die in der präoperativen Diagnostik erhobenen Befunde in der Perinealsonographie und Urodynamik unterstützen das klinische Bild hier. Vor allem Trichterbildung und früher erster Harndrang erscheinen wichtig. Das Verhältnis der wegen Drang durchtrennten Bänder zu dem der wegen Obstruktion durchtrennten Bänder liegt dabei bei ca. 1 : 2. Schlussfolgerungen: Klinische Multizenterstudien müssen an einem groûen Kollektiv die Wertigkeit der potenziellen Risikofaktoren überprüfen, um durch bessere präoperative Selektion potenzielle Kandidaten für Abstract Aims of Study: Publication of the Swedish 5-year study after TVT-Implantation showed excellent results and few urgency or obstructive voiding side effects. In our collective of 750 TVT patients, however, a total of 45 women developed urgency or residual volume requiring TVT-dissection. As these side effects are difficult to treat, we examined the cause of this discrepancy by reevaluating our data in terms of the Integral Theory proposed by Peter Petros and Ulf Ulmsten. Methods: All available data on TVT-only patients and those patients included in this investigation were analysed. The patients were followed-up after 6 weeks, 6 months, one year and every year thereafter. They received a urodynamic study before and 6 months after surgery that included pre-and postoperative cystogram or, for the last 4 years, perineal ultrasound. Both quality of life investigation and vaginal examination were performed. The preoperative examination and second postoperative appointment also included registration of the electrical potential of the pelvic floor muscles. Results: In addition to the operative technique, which may result in incorrect positioning of the tape, weak pelvic floor muscles, subvesical and suburethral vaginal mobility as well as ...