Objective to refine the method of incisional biopsy in the diagnosis of oral mucosa cancer using the auto-fluorescent stomatoscopy. Materials and method.The study was conducted on the base of the Samara Regional Clinical Oncology Center. The inclusion criterion for patients was the diagnose of the oral mucosa cancer of various localization. Patients were divided into 2 groups. The main group included patients (n=43), who were being diagnosed for cancer with the help of optimized incisional biopsy of the oral mucosa formations, using the "AFS-400" autofluorescence complex and glasses with a green light filter for identification. The patients of the control group (n=46) received the standard biopsy procedure under direct vision. Results.The first incisional biopsies revealed cancer in 25 (54%) patients of the control group and in 36 (84%) patients of the main group. A histological verification of the diagnosis was necessary in 7 (16%) patients of the main group and required the second biopsy. In the control group, for the same purpose, 17 (37%) patients underwent the second biopsy and 4 (9%) patients required the third biopsy procedure. Exophytic-papillary forms of cancer were the most complex for histological verification. The primary biopsy of these cases was effective in 16 (37%) patients in the main group and in 8 (17%) patients in the control group (p = 0.036). In patients with initial stages of cancer (I-II), with the first incision biopsy, the histological verification of cancer was achieved in 16 (37%) cases in the main group and in 8 (17%) cases in the control group (p = 0.036). Conclusion.The use of the "AFS-400" autofluorescent complex and glasses with a green light filter for incisional biopsy of oral mucosal formations allows histological verification of cancer with the first biopsy in 84% of cases, including in stages I - II in 16 (37%) cases and in exophytic papillary forms in 16 (37%) cases. The significant difference was registered for the similar indicators of the control group (p = 0.036).

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The chondrosarcoma of the larynx is a poorly understood and rare malignant tumour. It accounts for only 1% of malignant neoplastic pathology of the larynx, but at the same time it is the most common non-epithelial neoplasm of the larynx. More often occurs in the area of the cricoid cartilage, namely the inner plate, less often in the area of the vocal folds and the epiglottis. There are no clinical guidelines for the treatment of chondrosarcoma of the larynx, therefore each clinical case describing clinical observations of this rare tumour is of interest. A clinical case of chondrosarcoma of the larynx is presented in a 55-year-old man who complained of hoarseness for 3 months. The patient underwent a complete clinical and instrumental examination, but computed tomography (CT) is of the greatest value. According to CT data, a calcified mass is visualized in the cricoid cartilage. At the first stage, the patient underwent resection of the cricoid cartilage in order to verify the diagnosis. Histological examination: low-grade chondrosarcoma. At the second stage, a radical surgical treatment was performed - laryngectomy. 8 months after the operation, the patient has no data on the relapse and progression of the disease according to the survey data. Currently, total laryngectomy is preferred for patients with recurrent low-grade chondrosarcoma. However, a literature review and our case show that the inability to restore the cricoid cartilage of the larynx, which is affected in most cases, often leads to laryngectomy