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Rationale. The article presents the data obtained by an improved method of contrast-enhanced ultrasound (CEUS) in patients with chronic viral hepatitis. Methods. We compared the quantitative and qualitative CEUS parameters in 2 groups of patients: the 1st group was administered 2.5 ml of the contrast agent, and the 2nd group was administered 1.0 ml of the contrast agent. Results. The results showed that the quantitative parameters had no statistical differences in the arterial and portal phases. Conclusion. The parameters of the late venous phase were not clinically significant, since the study objective included the assessment of diffuse liver disease, not focal liver lesions.

The pilot results of the contrast — enhanced ultrasound (CEUS) application in the liver parenchyma assessment are presented in this article. 65 people aged 37 to 69 years were examined, 41 of them (63 %) with chronic viral hepatitis and 24 people (37 %) with established diagnosis of liver cirrhosis as the outcome of viral hepatitis. All patients underwent multiparametric ultrasound examination: ultrasound of the liver in B — mode, color Doppler’s mapping of liver vessels, 2D — Shear Wave Elastography (2DSWE) and CEUS. Liver biopsy and D — Shear Wave Elastography (2DSWE) were used as the reference method.

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