In a patient with pigmented villonodular synovitis of the right knee joint, there occurred a malignant giant cell tumor of tendon sheath. There was clinical evidence of metastasis after the second local recurrence and the recurrent tumors were studied enzyme cytochemically and electron microscopically. Ultrastructurally, the malignant tumor consisted of three principal cell types; histiocyte‐like cells, fibroblast‐like cells, and intermediate cells, with unique attendance of myofibroblasts. This may be the first report of the presence of myofibroblasts in malignant giant cell tumor of tendon sheath. Enzyme cytochemistry revealed various functional properties of histiocytes. ACTA PATHOL. JPN. 35 : 699–709, 1985.

Three Japanese patients with carbonic anhydrase II (CAII) deficiency from three families were described. The parents of one patient were unrelated, the parents of each of the other two patients were first cousins. All the patients had renal tubular acidosis, osteopetrosis, symmetrical cerebral calcification and mental retardation. They exhibited poor activity and poor appetite in the neonatal period, and then developed psychomotor retardation. Two of them were diagnosed as having osteopetrosis at 10 months and 36 years of age, respectively, and the other as having osteomalacia at 28 years of age. All patients had recurrent episodes of muscle weakness. The CAII enzyme activity and protein levels in red blood cells in each of the three patients were deficient. Their parents exhibited approximately 50% normal levels of CAII activity and protein. This is the first report of patients with CAII deficiency in the Japanese population.

A 3-year-old boy developed idiopathic thrombocytopenic purpura (ITP) and Perthes' disease concurrently. Antiphospholipid antibodies were detected in the serum of the patient. Therefore, it is possible that Perthes' disease in this patient might be one of the manifestations of ITP-associated antiphospholipid syndrome.

We investigated soccer sports injuries and trauma in junior high school athletes in Saga prefecture by questionnaire and direct examination.Regarding past history of injury, sprain was the most common. 212 (26.4%) athletes were not satisfied with their play due to pain and its after effects. As a result of direct examination, knee injuries comprised 46.3% of all injuries and of all knee injuries, Osgood-Schlatter's disease was the most common. Osgood-Schlatter's disease occurred more often in the opposite side rather than in the predominant side.It was thought that pain in the spina iliac anterior inferior area was due to repetitive and excessive traction force for the insertion of rectus femoris muscle caused by the muscular force itself and the transmitted impact-force at kicking the soccer ball.In order to prevent chronic injuries in the junior high school athletes, we emphasize the effectiveness of sufficient stretch for the muscles of the lower extremities.

No abstract