Garenoxacin Mesylate (GRN) is a quinolone antibacterial agent for the management of bacterial illness. The established method illustrates a development of simple, specific and robust method for the analysis of GRN using a reversed phase high-performance liquid-chromatography method on PrincetonSPHERE ULTIMA C18 column (250 mm x 4.6 mm, 5 μm) with PDA detection was carried out at 280 nm. A seven-factor eight-run Taguchi design was applied to factor screening studies and central composite design with α = 1 was utilized to optimization of experimental parameters of RP-HPLC for obtaining anticipated chromatographic resolution. Risk assessment, examine was executed to understand the basic method parameters. From the risk assessment three independent parameters such as percent acetonitrile content, mobile phase pH and flow rate were selected and study the impact of these parameters on the responses. From the design information the optimized chromatographic conditions comprises of acetonitrile: water in the ratio of 60:40 % v/v, pH 3.5 of aqueous phase marked using 0.1 % ortho phosphoric acid, separately. The percent recovery study was executed at three levels, was obeyed in the range of 99-101 %. Additional the method was validated as per ICH guidelines.

Background: Ritonavir (RTV) is an anti-retroviral drug used in the treatment of HIV/ AIDS. Many times, RTV is used alone and in combination with many anti retroviral drugs. So far, around seventy nine analytical methods have been reported for various studies on analysis of RTV in bulk, pharmaceutical formulations and biological fluids. Aim: To summarize the various analytical techniques such as Chromatog raphy, Spectrophotometry; Capillary electrophoresis and also hyphenated techniques such as LC-MS/MS for estimation of Ritonavir. Method: The present article deals with the comprehensive de tails about the type of various analytical techniques such as Chromatog raphy, Spectrophotometry; Capillary electrophoresis and also hyphenated techniques such as LC-MS/MS, and their applicability in analysis of RTV. These techniques are either explored for the quantification, detection of metabolite and also for stability-studies of the RTV. Conclusion: The present studies re vealed that HPLC technique along with the spectro-scopic have been most widely explored for the analysis. The investigatory review may provide the comprehensive details to the researchers who are working in the area of analytical research of RTV.

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Background: Indapamide is a diuretic of particular importance in an antihypertensive therapeutic regime that is profoundly applied to treat hypertension. Besides using as an individual drug for its diuretic and thereby antihypertensive effect, the drug is also a part of crucial combinations with Angiotensin-Converting Enzyme inhibitors. The recent combinations of Indapamide with Perindopril and Delapril work as the best therapies for heart patients. Purpose: Considering the therapeutic and pharmaceutical importance of the drug molecule and its potential to be explored in future drug discovery and delivery, we made efforts to portray the pharmaceutical analytical profile of the drug molecule at ease. Method: The present article is a composition entailing the comparative and critical evaluation of the various analytical approaches explored for the pharmaceutical estimation ofIndapamide as a particular drug in combinations and pharmaceutical as well as biological matrices. The analyses are reviewed for the specificapplications of analytical methods tested Indapamide alone or with other medications. Result: The anticipated study revealed the comparative usage of different research techniques for Indapamide estimation. The study influences the possibility of constraints and focuses on the recent trend in Indapamide analysis. The article also provides an understanding of sample processing, drug extraction method, validation protocols/approaches, and stability studies, including but not limited to the bioanalytical perspectives. Conclusion: This review can be explored thoroughly for the future analytical and pharmaceutical insights of Indapamide to the fullest.