The methanol extract of Diospyros peregrina (Ebenaceae) bark (MEDP) were evaluated for antitumor activity against Ehrlich ascites carcinoma (EAC)-bearing swiss albino mice. The extract was administered at the doses of 200 and 400 mg/kg body weight per day for 14 days after 24 h of tumor inoculation. After the last dose and 18 h fasting, the mice were sacrificed. The present study deals with the effect of MEDP on the growth of transplantable murine tumor, life span of EAC-bearing hosts and hematological profile MEDP caused significant (P < 0.01) decrease in tumor volume, packed cell volume, and viable cell count; and it prolonged the life span of EAC-tumor bearing mice. Hematological profile converted to more or less normal levels in extract-treated mice. The results indicate that MEDP exhibited significant antitumor activity in EAC-bearing mice.

The purpose of the study conducted was to know the extent of protection over the cancer associated metabolic syndrome development after administration of ethanol and aqueous extracts of Drosera peltata J.E.Sm against Dalton's ascites lymphoma (DAL) and Ehrlich's Ascites Carcinoma (EAC) bearing mice. Animals were divided into thirteen groups with a normal control, EAC control, DAL control, two groups with standard drug 5-Flurouracil 20mg/kg+ DAL & EAC and eight groups with 250 and 500mg/kg of ethanol and aqueous extracts of D.peltata J.E.Sm + EAC & DAL, for respective cell lines. After 24h of both tumor cell inoculations, animals were treated with extracts, once in a day for 14 days continuously. The indicators for the development of metabolic syndrome such as changes in blood glucose, serum hormone and lipid profile were found with both cell line bearing mice. Both ethanol and aqueous extracts of D.peltata J.E.Sm at doses of 250 and 500mg/kg significantly reduced the elevated blood glucose, hormonal and lipid profile changes. These results confirmed that ethanol and aqueous extracts can stabilize the tumor induced hormonal, blood glucose and lipid profile changes in tumor bearing mice. This effect might be due to the presence of pharmacologically active phytoconstituents in extracts.

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