The material on registration of malformation has been studied in Bukhara region for 2010. Out of 159 infants, born with different intrauterine anomalies the 16.35% (26) were found with the cleft lip and palate in different variants. After the complex examination by specialists (surgeon, pediatrician, orthopedist, otolaryngologist, psychoneurologist) operative treatment was conducted depending on degree of the defect. The study of the condition of immune system in infants was conducted after operative treatment. The examined were divided into 2 groups-infants without postoperative complications and infants with postoperative complications. We studied the quantitative determination of lymphocytes with phenotype CD3, CD4, CD8, CD16, concentration IgG, IgA IgM, phagocytic activity of neutrophils and the level of CIA. It was found that in infants with congenital cleft lip and palate exist the deflections on the condition of immune system, which were more denominated in infants with postoperative complications.

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For a dentist, it may be of practical interest to find out the role of psycho-emotional factors and features of the patient's psychotype in the formation of his motivation and compliance to orthopedic treatment.

Inflammatory diseases of the oral mucosa can manifest themselves by various nosological processes of the oral cavity, but sometimes even against the background of pronounced inflammatory processes, stomatitis, gingivitis and many other diseases do not form, often this is due to systemic viral processes, for example, coronavirus infection. At the same time, clinical symptoms can be very diverse, or even absent even against the background of changes in the immune and microbial landscape of the oral cavity. With the progression of the disease, the process may spread to the palate, gums, palatine tonsils, larynx, and digestive tract. It is important to distinguish weakened individuals, individuals with immunodeficiency conditions who were on long-term use of antibacterial agents, corticosteroids and antineoplastic drugs. The persistence and recurrent nature of such inflammatory lesions requires not only the usual hygienic measures for the care of the oral cavity and teeth, but also appropriate justified therapy aimed at stimulating the protective forces of the oral mucosa.