The article presents data on the establishment of the effectiveness of intrauterine administration of the experimental herbal preparation Fit-O-Metrin based on extracts of thyme, oregano and barberry in postpartum endometritis in sows. Inflammation of the mucous membrane of the uterus is a fairly common disease of the genitals in sows, especially after farrowing, which often occurs against the background of viral infection due to bacterial or parasitic contamination of the uterus, as well as due to violation of veterinary rules of pigs and feeding poor quality feed, fungus and their toxins. In most cases, endometritis in sows secretes bacterial microflora and is treated with drugs to which the microflora is not resistant or use new broad-spectrum antibiotics, but it is known that they act not only on its microflora but also saprophytes of the vagina and its dorsum, turn may be the etiological factor of settlement in these organs of antibiotic-resistant bacteria. Treatment of 20 sows of the control group was carried out according to the protocol adopted in the farm: Cobactan at a dose of 4 ml per 100 kg intramuscularly, once a day for 3 days, Dexafort at a dose of 1 ml per 50 kg, intramuscularly, once, Introvit in dose of 10.0 ml per animal, intramuscularly once, Catozal at a dose of 10.0 ml per animal, intramuscularly once, Galapan at a dose of 2.0 ml per animal intramuscularly, once. 10 animals of the experimental group to this protocol in the uterus was injected Fit-O-Metrin drug at a dose of 30.0 ml once. During the studies, the duration of exudate secretion after the end of treatment was taken into account and a sonographic examination of the uterus was performed, in addition, the nature of uterine secretions before insemination was taken into account. 30-35 days after insemination with the help of a sonographic device examined the condition of the uterus of sows to diagnose pregnancy or infertility. The prevalence of postpartum catarrhal-purulent and purulent endometritis among sows after farrowing was 25.0 %, purulent exudate was excreted in 30 % of sick animals, in the rest (70 %) purulent-catarrhal exudate flowed from the vagina. After using Fit-O-Metrin drug for postpartum endometritis in sows, the number of animals admitted to insemination increased by 55.0 % (p≤0.001), and their fertility by 34.4 % (p≤0.05).

During the analysis of the age of heifers, in which they became pregnant, it was found that 28.5% of animals were fertilized before 14 months of age. However, 45.2% of heifers became pregnant from 14 till 17 months. At the age from 17 till 20 months, 23.6% of heifers became pregnant. At least 2.7% of heifers were inseminated after reaching the age of more than 20 months. A frequency analysis of calving complicated course firstborn depending on age heifers during fertilization showed that it has noted and a third of fertilized heifers under 14 months of age and a group of 17 and up to 20-months. The frequency of complicated calving was lower by 7.9% in first-born cows that were fertilized at the age of heifers from 14 to 17 months., Than heifers first and third groups. In firstborn fertilized after 20 months of age and complications is calving were recorded in 50.0% of cases. Analysis of spread of Art and complicated course calving cows of different age groups depending on the number of previous families showed that it observed in 24.7% of all cows animals that calved. The largest of the share was 16.3% firstborn. Cows at the second calving or impeded his progress noted a 4.9 times fewer animals and in cows third calving share its complications decreased 12.5 times relatively firstborn. Animals of the fourth and subsequent calving we are number of complications was smaller group of first fruits of 4.3 times (p ˂0,001). The frequency of culling cows in the herd was 23.7%. And the analysis of the structure of culled cows depending on the age and period of lactation showed that during 90 days of lactation 57.5% of cows dropped out. Every fourth cow dropped out at the end of lactation. First-born 47.2% of all culled cows were most often culled of all cows rejected. Animal second lactation dropped to 1.55 times (p ˂0,01) less or the same first-born, and cows third and fourth lactations or more dropped to 2.8 - 2.6 times (p ˂0,01) less than cows of the second lactation. Most first-born 24.2% were culled during 90 days of lactation, cows of the third and fourth and more lactations dropped out 3.6 and 3.3 times (p ˂0.05) less. At the end of lactation, 15.3% of first-born cows dropped out, which is 9.7% more than cows of the second lactation and 12.9% more than cows of the third and fourth and more lactations.

Nowadays only 30–50% of inseminated cows actually calve and the majority of pregnancy loses happens during the first 2–3 weeks after insemination. Fertility rate of heifers and cows with average milk production is from 90% to 100%, but in high producing animals that are influenced by stress, such rate can be reduced to 80%. Our experimental researches were conducted in conditions of dairy farms of Poltava and Kharkiv regions of Ukraine in summer of 2020. Estrus synchronizing in cows was started from 50-60 days after calving in Summer time. To prevent Infectious Rinotracheitis, Viral Diarrhea, Parainfluenza 3 in dairy herds cows were vaccinated with polyvalent vaccinations usually before or at the beginning of dry period. Before estrus synchronization trans-rectal sonographic examination was done in all cows to determine condition of uterus and ovaries. During the trial the herd of cows was divided in two groups depending on length of period from calving to estrus synchronizing. In the first group were cows up to 90 days after calving, in the second group – 91 and more days. We registered that Estrus synchronization accordingly to OVSYNCH protocol in 50-90 days (first group) and 91 and more days (second group) after the calving and using Surfagon on day 5 after insemination promote an increasing of cows fertility in the second group on 5.8% compare to control. At the same time combined using of Surfagon on 5-th and Ainil on 11-th day after insemination in cows of first group promotes their fertility on 7.5% compare to control animals of this group, and in the second group this increased on 12.6%. At the time of repeated pregnancy diagnostic of cows in 60-65 days there was established absence of previously determined pregnancy in 5.0-11.0% of animals, that was the evidence of late embryonic death. When Surfagon was used in cows on day 5 after insemination frequency of embryonic death was decreased in 1.7 times or by 4.7% compare to the control group of cows. Combined using of Surfagon on day 5 and Ainil on day 11 promoted decreasing of embryonic death in 2.3 times or by 6.4% (p≥0.05).