Premolars have been blessed for having an aberrant root canal anatomy. The occurrence of more than 2 canals with different portal of exit is very rare. If one is facing the scenario of treating the maxillary and mandibular premolars clinically than he must be aware of the internal anatomy of these teeth. These teeth may require special shaping and obturating techniques. This case series is the reflection of the endodontic challenges clinicians face to manage such cases. Careful examination of pre-operative radiograph and careful negotiation is necessary to deal with such variable anatomies.

Aim: Using N acetyl cysteine (NAC) and Chlorhexidine as final irrigants, the study aims to examine the push out bond strength of distinct sealers. Materials and Methods: Access and biomechanical preparation were done on decoronated 80 single-rooted teeth. Canals were alternatively irrigated using 5ml of 5.25% NaOCl and 5ml of 17% EDTA solution during instrumentation. On the basis of final irrigation procedure, the samples are divided into two groups: Group 1 – NAC and Group 2 – 2% Chlorhexidine. Using paper points, canals were dried and subdivided depending on the sealers used, Group 1A and 2A- AH plus and 1B and 2B- BioRoot RCS. Teeth were obturated and middle root sections were tested for push-out bond strength using universal testing equipment. Statistical analysis was done. Results: NAC with AH-plus sealer had the maximum push-out strength, whereas Chlorhexidine with BioRoot RCS sealer had the lowest. Conclusion: NAC increases the bond strength of the obturating materials as the final irrigant. NAC can be considered as a final irrigant for endodontic therapy.