Extracts of leaves of Tephrosia purpurea and tuber of Alocasia indica were used as a traditional medicine in India for the management of various diseases, including rheumatic arthritis, hepatoprotective activity and antifungal properties.  The objective of the work is to standardize the phytochemical constituent and comparatively analyze the anti-oxidant activity of Alocasia indica and Tephrosia purpurea. Leaves ethanolic extract of Tephrosia purpurea and tuber ethanolic extract of Alocasia indicia Schott. were evaluated for antioxidant activity using 1, -diphenyl-2-picryl hydrazyl (DPPH) assay. Phenolic content was estimated by using Folin-Ciocalteu's reagent. Total flavonoid content was measured for Alocasia indica and Tephrosia purpurea by the aluminum chloride colorimetric assay. Furthermore, Albino mice were used to test the acute toxicity of the plant extracts.  The standardization of plant extracts demonstrated lesser amount of oil-soluble contents is present in both the plants. The total flavonoid contents were 76.93±1.41 and 107.44±1.89 mg QE/g while the total phenolic contents were 512.33±1.52 and 595.66±2.51 mg GAE/g for A. Indica and T. Perpurea, respectively. The antioxidant assay illustrated, significant DPPH radical scavenging potency of plant extracts.

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Ailments with ignescent etiopathology have expanded in rate lately. Medications utilized for restorative administration of such provocative ailments are alleviating the disease and yet additionally countering genuine perilous outcome. Allopathic medications really pejorate the disease condition in patients, particularly with rheumatoid joint pain and osteoarthritis. Add to this the huge number of individuals detriment by these medications, as well as their huge expenses and the need of using reciprocal means become obvious. On the other hand, natural medicines offer one engaging approach to decrease the use of allopathic non- narcotic anti- phlogistic agents. The reason for administering herbs incorporate long accounts of utilization, a broad examination on various natural constituents, the relative simplicity of administration profile, economical and magnificent security records. So far, Many Phyto-constituents are investigated for numerous therapeutic applications, albeit a large fraction of these reports are of scholarly interest, only some of them get a pass for clinical preliminaries. Future exploration should look into the molecular mechanisms of various therapeutic applications of the natural plants in different ailments associated with inflammation. This review is a compilation of anti-inflammatory natural agents along with reported action path. We have summarized all necessary information regarding the title with the aid of best possible sources.

Using 18-beta-glycyrrhetinic acid, a well-known component of licorice (Glycyrrhiza glabra Lin.), the current study offers a unique rapid ecological & simple approach of biologically synthesizing of silver nanoparticles (AgNPs). To synthesise stable silver nanoparticles via a biological reduction technique, a methanolic stock solution of 18-β-glycyrrhetinic acid was produced and used as capping and reducing agent. The approach was methodically optimized using response surface analysis (RSA) based Box-Behnken design (BBD), taking into account influence of parameters like as silver nitrate (AgNO3) concentration, incubation time and temperature on response. RSA was utilized to determine the association among factors and the responses by mathematical modelling with a quadratic polynomial model. AgNO3 (1mM), 55°C, and 5 hours incubation were optimal. 18-β-glycyrrhetinic acid methanolic stock solution can convert silver ions (Ag+) into silver nanoparticles (AgNPs) in 5 hours at 55°C. Biosynthesized and optimized AgNPs have an SPR absorption peak at 419 nm in their UV spectra. 18-β-glycyrrhetinic acid reduced and capped silver ions according to FTIR spectroscopy. XRD showed AgNPs’ crystallinity. SEM revealed spherical elemental silver with particle size of 100 nm. Average particle size, PDI & Zeta were 83.36 nm, 0.462 and -35.4mV, respectively, at 100% intensity. Silver nanoparticles (GAAgNPs) are stable. DPPH experiment showed substantial antioxidant activity in GAAgNPs compared to ascorbic acid. At 10 μg/mL, AgNPs showed utmost region of inhibition of 15 and 14 mm against Staphylococcus aureus and Pseudomonas aeruginosa, respectively. Finally, the synthesized AgNPs and their quality components have strong antioxidant and antibacterial activity, indicating that this research can be used to formulate useful biomedical goods.