One-hundred-four women who met Research Diagnostic Criteria for nonpsychotic, nonbipolar Major Affective Disorder were treated in 21 therapy groups for 10 weekly 1 j hr sessions. Three versions of the self-control therapy program for depression, one with a behavioral target, one with a cognitive target, and one with a combined target, were used to treat 7 groups each. AH conditions improved significantly and equally on self-report and clinician rating scales of depression. All conditions improved equally on measures of both behavioral and cognitive target variables, and initial level on these variables was not related to outcome.The self-control therapy program for depression is based on a model (Rehm, 1977(Rehm, , 1981a(Rehm, , 1982 that assumes that depression can be characterized as a series of specific deficits in selfmanagement behavior. This highly structured, group-format therapy program has been developed and evaluated as a research tool. Two studies (Fuchs & Rehm, 1977;Rehm, Fuchs, Roth, Kornblith, & Romano, 1979) validated the program against control conditions, and two additional studies disassembled the program package to evaluate its separate self-management components (Kornblith, Rehm, O'Hara, & Lamparski, 1983;Rehm et al., 1981). The program has been used by other researchers in disassembly (Tressler & Tucker, 1980) and comparison studies (Fleming & Thornton, 1980;Roth, Bielshi, Jones, Parker, & Osborn, 1982). The program has also been extended to other populations, including community mentalhealth-center patients (Glanz & Dietz, 1980), psychiatric inpatients (Kornblith & Greenwald, 1982