Adelmo C. Aragão-Neto scite author profile

Galactomannan films from Cassia grandis seeds, associated or not with Cramoll 1,4, were used on topical wounds of rats for the evaluation of the healing process during 14days. All of the films were evaluated by cytotoxic assay, FTIR and lectin hemagglutinating activity (HA). Forty-five male rats were submitted to aseptic dermal wounds (Ø=0.8cm) and divided in groups (n=15): control, test 1, and test 2, treated respectively with saline, galactomannan film and film with immobilized Cramoll 1,4. Macroscopic evaluations were performed by clinical observations and area measurements, and microscopic analysis by histological criteria. Epithelial cell proliferation and differentiation was immunohistochemically assessed using CK14 and PCNA. The presence of CO peaks in the FTIR spectrum confirmed the immobilization of Cramoll 1,4 in the film, while the residual HA confirmed the stability of the lectin after immobilization with 90.94% of the initial HA. The films presented non-cytotoxicity and cell viability exceeding 80%. All of the animals presented re-epithelization around 10days, furthermore test 2 group showed a diffuse response at the stromal tissue and the basal layer associated with wounds completely closed with 11days of experiment. The results suggest a promising use of the films as topical wound curatives.

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Healing activities of Cramoll and xyloglucan membrane in cutaneous wounds of diabetic mice

Andrade

Neves

Albuquerque

et al. 2021

Journal of Immunology and Regenerative Medicine

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Head and Brain Trauma among Children and Adolescents at a Public Hospital in Recife, Brazil

Orestes-Cardoso

Aragão-Neto

Orestes-Cardoso

et al. 2013

cmbio

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Introduction: The Head and Brain Trauma (HBT) have a great potential to cause sequelae, therefore extremely important for the health professionals. Objective: The aim of this paper is to provide an epidemiological overview about HBT in a high complex health unit located in Recife, PE, Brazil. Methodology: Risk factors were divided in: Urban Violence (Road accidents, Running Over,Firearm, Physical aggression and Melee weapon) and Non-Urban Violence (Falls, Accidental Trauma, Sports and others). Statistical analysis was performed using descriptive and inferential techniques, such as: Fisher exact test, Chi-square test, and likelihood-ratio test. The statistical significance was set at 5%. Results: HBT was present in 5.5%, predominantly between ages ranging of 0 to 19 years old (17.6%). In this amount, the male gender had higher values than female, being the most affected the age ranging from 15 to 19 years, presenting a ration of 2.4:1. Concerning etiological factors, Non-urban-violence was present in 87.8%, occurringpredominance in age ranging from 0 to 1 year old (96.2%). Conclusion: It was found prevalence of accidents among the male gender, which is a constant observed also in several other studies, however, a more alarming factor is the high rate of accidents involving young children, being indispensable the parents necessity of work, they received only essential care, being under thetutelage of older brothers, neighbors, and even non-nuclear relatives.

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