Background and Objective:COVID–19 is a newly emerging disease and considered an emergency health problem, worldwide.It has a wide range of clinical features, from mild fever to severe respiratory failure that leads to a higher mortality rate. Previous studies state that CRPhas a very strong positive correlation with the diameter of the lung lesion, and in intensive care patients had a higher level of LDH. This study aims to determine the correlation between CRP, LDH and disease severity and mortality in hospitalized COVID-19 patients. Methods: We conducted a retrospective cohort, a single-center study including  69 laboratory-confirmed patients in our hospital in Malang City, Indonesia from April - June 2020. Result: Subjects consisted of 26 patients (37.7%) in the mild-moderate group and 43 patients in severe group (62.3%).Statistical analysis showed CRP and LDH associated with disease severity (p=0.011 and p<0.001). Analysis of CRPand LDH in survivor and non-survivior group showed that CRP and LDH also asscociated with mortality in hospitalized COVID-19 patients (p=0.034 and 0.002). We also evaluate CRP and LDH with degrees of hypoxemia  by assessed P/F ratio. Statistical analysis showed that CRP did not correlate with degrees of hypoxemia (p=0.079) but LDH inverse correlate with degrees of hypoxemia (p<0.001, pearson correlation = -0,489)  Conclusion: In our retrospective cohort study demonstrated LDH and CRP can be a crucial indicator to predict severity and mortality for hospitalized COVID-19 patients and LDH may usefull test for predict early identification of patients who become respiratory failure or ARDS. Keywords: COVID-19, LDH, CRP, P/F Ratio

Background: Coronavirus Disease emerge as a new global health crisis. COVID-19 has a wide range of clinical feature, from mild cough to severe respiratory failure. This study aims to learn more about clinical feature of This cross sectional analytic descriptive study includes all COVID-19 patients that yield positive result through GeneXpert-SARS-CoV-2 or Polymerase Chain Reaction (PCR). All data was taken from inpatient form March 12 th -June 30 th 2020. Results: There were 103 patients with 58 men and 45 women. Patients with male sex tend to experience severe pneumonia than women. It was also found that patients exposed to cigarette smoke tended to experience severe pneumonia symptoms. Patients with more than 1 comorbid tend to develop severe pneumonia symptoms. The dominant clinical symptoms in the patient were cough (84.5%), fever / history of fever (70.9%), and shortness of breath (67.9%). Hematological parameters that correlate with the degree of severity are leucocytes, thrombocyts, lymphocytes, neutrophils, CRP, LDH, creatinine, procalcitonin, SGOT, and SOFA Score. The most common radiological picture obtained was bilateral infiltrate (78.2%). The most common complication was sepsis (38.9%). The mortality rate for COVID-19 patients treated at RSSA tends to be high (26.2%). Discussion: clinical characteristics such as gender, smoking history, comorbides, clinical symptoms (fever, shortness of breath and cough), laboratory (leukocytes, % lymphocytes, % neutrophils and neutrophil counts, CRP, LDH, procalcitonin, creatinine, SGOT, and SOFA scores) has a significant effect on the severity of Covid infection 19 Conclusion: The clinical characteristics of COVID-19 patients affects the severity of the disease.

Pendahuluan: Saat ini COVID-19 masih menunjukkan peningkatan dalam hal prevalensi dan mortalitasnya. COVID-19 mempunyai gejala berupa demam, batuk kering, fatique, dan kemudian berkembang menjadi sesak napas sampai gagal napas dan ARDS. Happy hipoxemia ditemukan pada sebagian pasien yaitu secara subjektif pasien tidak menyatakan adanya sesak, namun didapatkan gangguan oksigenasi. Diperlukan suatu parameter untuk mengevaluasi derajat oksigenasi pada semua pasien COVID-19 yang dapat menjadi prediktor derajat keparahan COVID-19 dan memberikan suatu gambaran untuk rencana tatalaksana lebih lanjut. Objective : Menganalisis hasil pemeriksaan Analisis Gas Darah pada pasien yang dirawat di rumah sakit dan hubungannya dengan derajat keparahan penyakit COVID-19.Metode: Analisis observasional dengan pendekatan cross sectional, single-center, pada 71 pasien terkonfirmasi COVID-19 dilakukan antara bulan April-Juli 2020 pada pasien yang dirawat di Ruang COVID RS Dr. Saiful Anwar Malang, Indonesia. Analisis statistik digunakan untuk menilai hasil analisis gas darah dengan derajat keparahan penyakit. Hasil: Subjek terdiri dari 71 pasien terkonfirmasi COVID-19 terbagi menjadi 2 kelompok, 25 pasien (35,21% ) kelompok ringan sedang dan 46 pasien (64,79%) kelompok berat. Demografis dan karakteristik klinis menunjukkan bahwa usia, riwayat merokok, keluhan sesak dan penggunaan oksigen berhubungan dengan derajat keparahan penyakit (masing masing dengan p<0,05). Analisis gas darah menunjukkan hubungan antara derajat keparahan penyakit dan derajat oksigenasi yang dinilai dari PaO2, SaO2 BGA, PaO2/FiO2 dan original PaO2 (masing masing dengan p<0,05). Kesimpulan: Derajat oksigenasi berhubungan dengan keparahan pasien COVID-19 rawat inap.

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