Asam urat adalah produk akhir katabolisme purin atau degredasi asam nukleat dari sisa makanan yang kita konsumsi. Pada manusia dikatakan Hiperurisemia apabila terjadi peningkatan kadar asam urat darah serum lebih dari 7 mg/dl pada lelaki dan lebih dari 6 mg/dl pada wanita. Untuk mencit dikatakan hiperurisemia bila kadar asam uratnya 1.7-3.0 mg/dl dengan kadar asam urat normal 0.5-1.4 mg/dl. Tujuan penelitian ini adalah untuk mengetahui “Evektivitas air alkali terionisasi sebagai anti oksidan terhadap penurunan kadar asam urat pada mencit jantan (mus muculus)” Penelitian ini dilakukan dengan metode eksperimental laboratorium, dimana mencit yang menjadi hewan uji diinduksi dengan potasium oksonat 300 mg/BB. Control positif dengan memberikan allopurinol 100 mg/kg BB, kontrol negative 0.2 ml/g BB. Sementara perlakuan adalah dengan memberikan Air Alkali (pH 8.5, 9.0, 9.5 dan 11.5 0. Sebanyak 0,0284 ml/g BB) setelah diberikan perlakuan kadar asam urat dicek dari jam 1.2.3 dan 4 sebagai data. Hasil penelitian menunjukkan bahwa terdapat perubahan rata-rata kadar asam urat pada kelompok 1 (kontrol negatif), 0.97% pada kelompok 2 (control positif), 0.68% padakelompokuji 3 (PH8,5), 0.93% kelompok uji 4 (PH 9.0). 0.96% kelompok uji 5 Data (PH 9.5). 0.93% dan kelompok terakhir kelompok 6 (PH 11.5) sebesar 0.72%. berdasarka npenelitian yang dilakukan dapat disimpulkan bahwa air alkali terionisasi mempunyai aktivitas anti hiperurisemia. Aktivitas tersebut signifikan pada pH yang digunakan (pH. 11.5) dengan persen penurunan sebesar 0.72% dibandingkan dengan pH yang lain.
Diabetes mellitus (DM) or diabetes is a disease caused by disorders related to the hormone insulin. Ginger, lemongrass and cinnamon are traditional plants that have the potential to be developed as herbal medicines. The combination of these traditional plants can be used as an alternative treatment for diabetes mellitus. Infusions of ginger, lemongrass and cinnamon contain secondary metabolites, namely flavonoids, terpenoids and tannins. These three active compounds have antioxidant, antidiabetic, and anti-inflammatory activities. The aim of this study was to determine the antidiabetic effect of the infusion of a combination of JSKM (ginger (Zingiber officinale), lemongrass (Cymbopogon citratus) and cinnamon (Cinnamomum verum)) on male mice (Mus Musculus). The design of this research is experimental with data analysis method using SPSS 16.0. Observation of healing time is done by observing the decrease in blood sugar levels for 7 days. In this study, 5 treatment groups were used, namely the negative control group (aquadest), the positive control group (glibenclamide), the P1 dose (162 mg/kgBW), the P2 dose (324 mg/kgBW), and the P3 dose (486 mg/kgBW). The most effective dose of the antidiabetic effect of JSKM infusion in male mice was in the P3 group with a dose of 486 mg mg/kgBW.
Alkaline water is water that has antioxidant content and has a structure that is rich in active hydrogen that can cure stomach ulcers. The purpose of this study was to determine the effectiveness of ionized alkaline water as an antiulcers in male white mice (mus musculus). Method of induction of gastric ulcer using aspirin, used as many as 24 male mice (mus musculus) aged 2-3 months used as mice test animals divided into 6 groups each group consisting of 3 animals all groups were given ulcer treatment for 7 days, then group I (negative control) were given aquadest group II (positive control) were given sucralfate, group III were given ph 8 alkaline water group IV was given ph 9.0 alkaline water, group V was given ph 9.5 alkaline water, and group VI was given alkaline water pH 11.5 treatment of each group for the next 7 days on the 14th day the mice were dissected and the gastric mucosa structure was observed and the mucosal damage value was determined. The results showed that alkaline water 9.5 and 11.5 had lower mucosal damage values than negative controls. It can be concluded that the alkaline water ph 9.5 and 11.5 are said to be effective in reducing gastric mucosal damage compared to the negative group given aquadest.
Daun duduk (Desmodium triquetrum (L.) DC.) mengandung tanin, alkaloid hipaforin, trigonelin, bahan penyamak, asam silikat, dan K2O. Tanin mempunyai efek sebagai antibakteri. Tujuan dari penelitian ini adalah untuk mengetahui aktivitas daun duduk (Desmodium triquetrum (L.) DC.) sebagai antibakteri dan untuk mengetahui kadar hambat yang sebanding dengan kloramfenikol. Jenis penelitian ini adalah penelitian eksperimental murni. Uji aktivitas senyawa antibakteri menggunakan metode difusi yaitu metode cakram. Sampel yang digunakan adalah infusa daun duduk (Desmodium triquetrum (L.) DC.) dengan kadar 4%, 6%, 8%, dan 10%, Kontrol negatif menggunakan aquadest, dan kontrol positif menggunakan kloramfenikol. Bakteri uji yang digunakan Staphylococcus aureus dan Escherichia coli. Kadar hambat yang sebanding dengan kloramfenikol sebagai antibakteri terhadap Staphylococcus aureus adalah 4% (3,784 ± 0,197); 6% (4,168 ± 0,177); 8% (4,596 ± 0,100) dan 10% (5,365 ± 0,221) cm, sedangkan pada Escherichia coli adalah 4% (3112 ± 0,024); 6% (4,124 ± 0,144) ; 8% (4,936 ± 0,243) dan 10% (5,272 ± 0,075) cm. Perlu dilakukan penelitian lebih lanjut uji daya antibakteri dari daun duduk dengan menggunakan bentuk sediaan dan bakteri lain
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