The contribution of acoustic dimensions to an auditory percept is dynamically adjusted and reweighted based on prior experience about how informative these dimensions are across the long-term and short-term environment. This is especially evident in speech perception, where listeners differentially weight information across multiple acoustic dimensions, and use this information selectively to update expectations about future sounds. The dynamic and selective adjustment of how acoustic input dimensions contribute to perception has made it tempting to conceive of this as a form of non-spatial auditory selective attention. Here, we review several human speech perception phenomena that might be consistent with auditory selective attention although, as of yet, the literature does not definitively support a mechanistic tie. We relate these human perceptual phenomena to illustrative nonhuman animal neurobiological findings that offer informative guideposts in how to test mechanistic connections. We next present a novel empirical approach that can serve as a methodological bridge from human research to animal neurobiological studies. Finally, we describe four preliminary results that demonstrate its utility in advancing understanding of human non-spatial dimension-based auditory selective attention.

Anatomical similarity across the neocortex has led to the common assumption that the circuitry is modular and performs stereotyped computations. Layer 5 pyramidal neurons (L5PNs) in particular are thought to be central to cortical computation because of their extensive arborisation and nonlinear dendritic operations. Here, we demonstrate that computations associated with dendritic Ca2+ plateaus in mouse L5PNs vary substantially between the primary and secondary visual cortices. L5PNs in the secondary visual cortex show reduced dendritic excitability and smaller propensity for burst firing. This reduced excitability is correlated with shorter apical dendrites. Using numerical modelling, we uncover a universal principle underlying the influence of apical length on dendritic backpropagation and excitability, based on a Na+ channel-dependent broadening of backpropagating action potentials. In summary, we provide new insights into the modulation of dendritic excitability by apical dendrite length and show that the operational repertoire of L5PNs is not universal throughout the brain.

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