Organophosphorus poisoning is a major global health problem with hundreds of thousands of deaths each year. Research interest in N-acetylcysteine has grown among increasing evidence of the role of oxidative stress in organophosphorus poisoning. We aimed to assess the safety and efficacy of N-acetylcysteine as an adjuvant treatment in patients with acute organophosphorus poisoning. This was a randomized, controlled, parallel-group trial on 30 patients suffering from acute organophosphorus poisoning, who were admitted to the Poison Control Center of Tanta University Emergency Hospital, Tanta, Egypt, between April and September 2014. Interventions included oral N-acetylcysteine (600 mg three times daily for 3 days) as an added treatment to the conventional measures versus only the conventional treatment. Outcome measures included mortality, total dose of atropine administered, duration of hospitalization and the need for ICU admission and/or mechanical ventilation. A total of 46 patients were screened and 30 were randomized. No significant difference was found between both groups regarding demographic characteristics and the nature or severity of baseline clinical manifestations. No major adverse effects to N-acetylcysteine therapy were reported. Malondialdehyde significantly decreased and reduced glutathione significantly increased only in the NAC-treated patients. The patients on NAC therapy required less atropine doses than those who received only the conventional treatment; however, the length of hospital stay showed no significant difference between both groups. The study concluded that the use of N-acetylcysteine as an added treatment was apparently safe, and it reduced atropine requirements in patients with acute organophosphorus pesticide poisoning.Organophosphorus (OP) insecticides are among the most important pesticides, and poisoning induced by them represents a major global health problem with hundreds of thousands of deaths each year, mostly in developing countries [1].Organophosphorus pesticides inhibit esterase enzymes, especially acetylcholinesterase, which results in accumulation of acetylcholine at cholinergic synapses and overstimulation of cholinergic receptors of the autonomic nervous system, central nervous system (CNS) and neuromuscular junctions [2].Acute toxicity produces a range of clinical manifestations, known as the acute cholinergic crisis. Depending on the type of receptors and their location, the clinical features may include muscarinic (bronchospasm,

In this study, 56 (14 control and 42 addicts) adult human subjects of both sexes of different periods of heroin dependence were subjected to the measurement of whole blood, serum, and red blood cell levels of some trace elements (zinc, manganese, iron copper, and bromine), as well as some major elements (phosphorus, sulfur, calcium, potassium, and chlorine). This was done by the energy-dispersive X-ray fluorescence (EDXRF) technique, in which copper and bromine showed a significant rise in whole blood (male) (22 and 32%, respectively), while zinc, iron, manganese, calcium, sulfur phosphorus, potassium, and chlorine showed a significant drop (49, 8, 25, 34, 21, 51, 61, and 72%, respectively) in proportion to the period of heroin intake (6 yr) and in comparison with the control group. No significant sexual variation has been reported.

The present study was carried out in order to assess the value of serum LDH in cases suffering from PEM. In this respect, total serum LDH and its isoenzyme pattern in conjunction with serum GPT, GOT, CPK, and HBDH were assayed in cases suffering from PEM and compared with normal control group. The study revealed that increased activities of total serum LDH in PEM are neither of cardiac nor of hepatic origins. The activities and significance of other enzymes studied suggested that skeletal muscles are the main sources for these increased activities of serum LDH in PEM. The study offered a strong evidence for discrimination of liver cirrhosis in PEM.

HighlightsSWAT soil water assessment was performed using soil water measurements.Dryland SWAT model soil water content was greater than the irrigated SWAT model.Using SWAT soil water estimates for real-time (daily) irrigation management purposes with the existing SWAT soil water subroutines and available soils data is considered risky.The surface layer showed the greatest soil water variability compared to deeper layers.Abstract. Soil water content (SWC) is a challenging measurement at the field, watershed, and regional scales. Soil and Water Assessment Tool (SWAT) soil water estimates were evaluated at three locations: the St. Joseph River watershed (SJRW) in northeast Indiana, the USDA-ARS Conservation and Production Research Laboratory (CPRL) at Bushland, Texas, and the USDA-ARS Limited Irrigation Research Farm (LIFR) at Greeley, Colorado. The soil water estimates were evaluated under two scenarios: (1) for the defined soil profile, and (2) by individual layer. Each site’s soil water assessment was performed based on the existing management conditions during each experiment, whether dryland or irrigated, and for various periods depending on SWC measurement availability at each site. The SWAT soil water was evaluated as follows: the Indiana site was evaluated under dryland conditions using daily soil water observations for one year; the Texas site was evaluated for a ten-year period under irrigated and dryland conditions using weekly soil water observations from four lysimeters; and the Colorado site was evaluated under irrigated conditions for a four-year period. The simulated soil water was evaluated by comparing the model simulations with observed daily and weekly soil water measurements at the three sites. Based on the results, even though all the SWAT models were considered to perform as good models following calibration (streamflow, ET, etc.), the soil water simulations were unacceptable for the defined soil profile and for individual layers at the three sites. Deeper soil layers had observations greater than field capacity values, indicating poor soil parameterization. The dryland model had greater water content than the irrigated model, contradicting the soil water measurements. This greater soil water simulation with the dryland model is a result of SWAT model uncertainties with ET reduction under dryland conditions due to water stress. This study indicated that soil water estimation using the default SWAT soil water equations has many sources of uncertainties. Two apparent sources resulted in the SWAT model’s poor performance: (1) SWAT soil water routines that do not fully represent soil water moving between layers to meet plant demand and (2) uncertainty in soil parameterization. Keywords: Hydrologic modeling, Soil moisture, Soil moisture sensor, Soil water, Soil and Water Assessment Tool.

No abstract