This experiment aims to determine the correlation of total phenolic and flavonoid content of jati putih leaves fraction (Gmelina arborea Roxb.) towards Antioxidant activity .  Sample was extracted by maceration method using ethanol 70% to obtain the ethanol extract (EE), followed by liquid-liquid extraction method to obtain fraction of ethyl acetate (EA) and n-Hexane (EH). The phytochemical screening  and determination of total phenolic and flavonoid content were done by colorimetric method. Antioxidant activity were done by DPPH, FRAP and ABTS methods. Phytochemical screening showed positive results for flavonoids, phenolic and saponins.  The largest total phenolic content was found on EA (11,59 µg/ml ± 0,3 %b/b EAG) and the largest total flavonoid content was on EA (3,88 µg/ml ± 0,02 %b/b EK). The total phenolic and flavonoid content of Jati putih leaves has a correlation with antioxidant activity. The coefficient correlation of activity on reducingDPPH radical was 56,7% (total of phenolic content) and 57,8% (total of flavonoid content) and on iron reduction power in FRAP method  was 99,9% (total of phenolics and flavonoids content). The relationship with the activity in reducing radical ABTS obtained coefficient correlation of 57,0% and 58,1% for total phenolic and flavonoids contents, respectively.

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Mulberry is considered as an important plant in traditional Chinese medicine, due to its various compounds, including phenols and flavonoids. These flavonoids have antioxidant activities so that can be a potential anticancer candidate. The aims of this study were to determining antioxidant activity, phenolic content, and potential anticancer activity in Mulberry stem extract. The extraction was carried out by maceration using ethanol as the solvent, antioxidant activity test using ABTS (2,2′-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid) method, phenolic content determination using Folin-Ciocalteu reagents, and anticancer activity test using the MTT (3-(4,5-dimetiltiazol-2-il)-2,5-difenil tetrazolium bromida) method on WiDr cancer cells and Vero cells. The result of total phenolic Mulberry stem extract was 35.9%, the antioxidant activity value was 83.18 µg / mL, the IC50 value for anticancer activity for WiDr cells was 71.24 µg / mL and Vero cells IC50 value was 154.241 µg / mL. It could be concluded that the Mulberry stem ethanol extract had strong antioxidant activity and had the potential anticancer selectively against cancer cells WiDr.

Bunga kacapiring (Gardenia augusta Merr) dan lemon (Citrus limon L.) merupakan tanaman yang mengandung beberapa senyawa aktif diantaranya yaitu flavonoid, saponin, alkaloid, dan tanin yang berkhasiat sebagai antibakteri, pada penelitian ini kedua bahan tersebut dibuat menjadi sediaan paper soap. Pembuatan sediaan paper soap ini adalah karena paper soap merupakan sebuah inovasi produk sediaan sabun yang unik yang lebih praktis, ringan dibawa kemana-mana dan dapat berkhasiat sebagai antibakteri. Tujuan penelitian ini adalah untuk membuktikan bahwa ekstrak bunga kacapiring (Gardenia augusta Merr) dan kulit lemon (Citrus limon L.) dapat diformulasikan menjadi sediaan paper soap dan untuk membuktikan bahwa formulasi sediaan paper soap ini memiliki aktivitas antibakteri terhadap Staphylococcus aureus. Metode penelitian ini merupakan penelitian eksperimental dengan evaluasi sediaan secara fisika dan kimia serta pengujian aktivitas antibakteri dengan metode difusi teknik paper disc. Hasil penelitian yang didapatkan adalah sediaan paper soap kombinasi ekstrak etanol bunga kacapiring (Gardenia augusta Merr) dan kulit lemon (Citrus limon L.) memiliki efek sebagai antibakteri terhadap Streptococcus aureus.

BACKGROUND: Moringa oleifera, Moringaceae, is a tree that is native to South East Asia. Various parts of this tree are commonly used in traditional medicine to treat inflammation, hepatitis, gastric ulcer, and other ailments. AIM: M. oleifera leaves extract was formulated into stable suspensions, characterized, and then evaluated for hepatoprotection activity against isoniazid. MATERIALS AND METHODS: The leaves were extracted using cold maceration, and suspensions of extract were prepared using sodium carboxymethyl cellulose (Na-CMC) as suspension agent at various concentrations (0.1, 0.5, and 1.0%). The formulations were analyzed by their appearance, color, odor, and taste. Density, pH, viscosity, re-dispersibility test, and sedimentation volume were observed. The stability of oral suspensions was analyzed in accelerated studies (5°C ± 2°C and 35°C ± 2°C for 12 h for 7 cycles) to find stable formulation, while the hepatoprotection activity was analyzed using an in vivo isoniazid-induced model. RESULTS: The appearance, color, odor, and taste of the suspensions were shown to be characteristic of the extract. Na-CMC at concentration 0.5% showed good physical properties. Stable suspension at dose 400 mg/kg BW per oral for 28 days exhibited a significant (p < 0.05) decrease in the serum glutamate oxaloacetate transaminase and serum glutamate pyruvate transaminase. CONCLUSION: Suspension containing M. oleifera leaves extract at 50 mg/5 mL was successfully obtained and showed physical properties that were appropriate and characteristic of this dosage form, suitable for hepatoprotection (400 mg/kg BW), making this an alternative to tablets.