Introduction: Braces often used in the treatment of malocclusion. However, in recent years malocclusion no longer becomes the reason for orthodontic treatment. Many people use it merely for a lifestyle purpose, and most of them got it from the dental quack. This study was aimed to understand the influencing factors of the citizen of Bandung preferences towards dental quack on constructing custom-made orthodontic appliances. Methods: This study was a cross-sectional study with purposive sampling technique consisted of 30 samples. The inclusion criteria were subject wearing dental quack custom-made orthodontic appliance; citizen of Bandung; and willing to participate in the study. Exclusion criteria were subject refused to participate in the study. Results: The study showed that most of the subject (73%) were using the treatment for the teeth alignment, and only a few were using for the lifestyle purpose only. From all subjects wearing orthodontic appliance, 63% of them were chosen dental quack custom-made orthodontic appliance due to the lower price, and 37% of the rest due to peer’s suggestion who had it before. The combination of the low income with the needs of orthodontic treatment and inadequate information regarding orthodontic appliance such as dental braces affected the subjects preferences towards the dental quack custom-made orthodontic appliance. Overall, the socioeconomic environment is the most influencing factor of preference. Conclusion: A lower price was the most influencing factor of high preferences for the dental quack custom-made orthodontic appliance.

Background. Breast cancer is one of the four types of cancer among women and is the most frequently diagnosed in most countries. Breast cancer occurs due to DNA damage and genetic mutations affected by exposure to estrogen, inheritance of damaged DNA, or pro-cancer genes such as BRCA1 and BRCA2. Therefore, a family history of ovarian cancer or breast cancer increases the risk of developing breast cancer. The embryo of the breast develops around the age of 6 weeks of pregnancy. Similar to breast development, fingerprint patterns also develop during the 6-13 weeks of pregnancy. Thus, the genetic message contained in the genome occurred during that period and was reflected in the dermatoglyphic pattern.Methods. The literature search was systematically used using PubMed, Cochran, Google scholar, and other Gray literature between 2010-2020. Of the 69 publications identified, 21 met the criteria and were included in the review. The review is carried out following the provisions of PRISMA (Preferred Reporting Items for Systematic Review).Results. This systematic review showed fairly consistent findings in breast cancer patients who tended to have more whorl fingerprint patterns and larger ATD angles. For radial loops, ulnar loops and arches were minor compared to the control group potential as an initial screening tool in at-risk groups.Conclusion. Long-term and follow-up studies with larger sample sizes in various ethnicities are needed to validate dermatoglyphics in anthropometric measurements as a promising marker of breast cancer.

Background Several studies have identified different genes that control the final dimension and structure of the mandible. Prognathism of the mandible is thought to correlate with these genes; however, no specific gene has been assigned as a risk factor due to various genome-wide scan results in different races. Previous studies that involved the Han ethnic group in China and Korea suggested matrilin-1 (MATN1) polymorphism as the contributor for mandibular prognathism. To date, no study has been conducted to understand the role of MATN1 in Deutero-Malay population. This study aimed to detect MATN1 gene polymorphism in the promoter and exon 5 regions, which is a proposed risk factor in class III skeletal malocclusion with mandibular prognathism in Deutero-Malay population. This was a case-control study with purposive sampling method that involved 47 class III skeletal malocclusion subjects with mandibular prognathism (case group) and 47 class I skeletal relation subjects (control group) performed in the Molecular Genetics Laboratory of Faculty of Medicine, Universitas Padjadjaran, Indonesia. DNA isolated from buccal mucous epithelia and MATN1 gene was amplified using the polymerase chain reaction (PCR) and sequencing technique. Data were then analyzed statistically to observe the frequency of allele/genotype MATN1 in class III skeletal malocclusion and mandibular prognathism patients in comparison with the normal mandibular as well as to identify the risk factor of mandibular prognathism. Result The frequency of the 354 T > C(rs20566) CC genotype gene polymorphism in the case group was significantly higher than in the control group. The odd ratio (OR) value of the case group was also higher than in the control group (χ2 = 4.89; p = 0.027; OR = 6.27). Conclusions Our results show that the polymorphism of 354 T > C in the exon 5 region of the CC genotype MATN1 gene is a risk factor for class III skeletal malocclusion with mandible prognathism in Deutero-Malay population.

Background: While some researches have claimed that Invisalign® is successful in creating meaningful tooth movement, there is still no comprehensive literature review that summarizes them using one valid and reliable parameter. American Board of Orthodontics-Model Grading System (ABO-MGS) is an objective measurement for the success of orthodontic treatment. This systematic review is determined to provide scientific pieces of evidence to prove the truth of the claim using ABO-MGS. Method: English-based health sciences journal databases were searched using "Invisalign" and "Model Grading System". The databases included in this study were Pubmed, Ebscohost, Google Scholar, ScienceDirect, and MEDLINE. Inclusion criteria were clinical cross-sectional, cohort, or case-control study using human subjects who finished Invisalign treatment. Two independent authors summarized the data from the obtained articles using predefined data fields and discussed the data result together. Result: Out of 60 studies found during the identification process, only 6 studies were included in the qualitative analysis. Only one of them studied the efficacy of Invisalign® by using ABO-MGS to measure the pre- and post-treatment model. Invisalign® mostly successful in creating change for alignment, overjet, and interproximal contact. Other categories were not that successful to be treated with Invisalign. Conclusion: Invisalign®‘s success is mostly pursued by correcting the malocclusion in the anterior region. Given the scarce amount of reliable evidence available, it is suggested that more studies are required to be able to draw a further conclusion.

Background. Breast cancer is one of the four types of cancer among women and is the most frequently diagnosed in most countries. Breast cancer occurs due to DNA damage and genetic mutations affected by exposure to estrogen, inheritance of damaged DNA, or pro-cancer genes such as BRCA1 and BRCA2. Therefore, a family history of ovarian cancer or breast cancer increases the risk of developing breast cancer. The embryo of the breast develops around the age of 6 weeks of pregnancy. Similar to breast development, fingerprint patterns also develop during the 6-13 weeks of pregnancy. Thus, the genetic message contained in the genome occurred during that period and was reflected in the dermatoglyphic pattern.Methods. The literature search was systematically used using PubMed, Cochran, Google scholar, and other Gray literature between 2010-2020. Of the 69 publications identified, 21 met the criteria and were included in the review. The review is carried out following the provisions of PRISMA (Preferred Reporting Items for Systematic Review).Results. This systematic review showed fairly consistent findings in breast cancer patients who tended to have more whorl fingerprint patterns and larger ATD angles. For radial loops, ulnar loops and arches were minor compared to the control group potential as an initial screening tool in at-risk groups.Conclusion. Long-term and follow-up studies with larger sample sizes in various ethnicities are needed to validate dermatoglyphics in anthropometric measurements as a promising marker of breast cancer.