Currently, there is a significant shortage of donor materials for replacing corneal tissue that is why it is relevant to create xenomaterials, which are able to replace a donor cornea with various types of keratoplasty. “Corneoplast” is a new medical device, which is a devitalized, fixed by the method of double crosslinking (dehydrothermic + UV), pork cornea.Purpose: to assess the biocompatibility and ability to integrate with the recipient cornea of implants based on the xenomaterial “Corneoplast”.Materials and methods. The experiment was based on biomicroscopy examination, high-resolution optical coherence tomography and histological examination of the experimental rabbits’ corneas (group I–IV: total of 8 eyes were examined), where keratoplasty was performed with the “Corneoplast” material.Results. High biocompatibility and ability to integrate with the recipient’s cornea were observed in all types of keratoplasty: penetrating, superficial lamellar and intralamellar keratoplasty. On the next day, the implant was transparent with slight swelling of the recipient’s corneal stroma. A week later, the slight swelling of implant was recorded without cornea edema. Its transparency decreased. The recipient’s cornea was reactive. A month later, the moderate neovascularization was noted towards the sutures. After 6 months, the recipient’s cornea was clear, transparent. The implant was translucent and neovascularization was absent. The entire surface of cornea and implant was epithelialized. On the series of optical coherent tomograms, a normal thickness of the epithelium continuous layer was determined in 6 months after the surgery. The complete integration of material with the recipient’s cornea was noted. The layered structure characteristic of corneal tissue was preserved. The cornea retained a layered structure and the endothelium was preserved. On histological examination, there were no differences in the intact cornea and implanted material.Conclusion. The “Corneoplast” material is sufficiently biocompatible and capable of integration with the recipient’s cornea in an animal experiment. This allows, at a certain stage of preclinical trials completion, to use it for replacing corneal tissue in penetrating keratoplasty, intralamellar and superficial anterior layer-by-layer implantations and to cover purulent corneal ulcers of various depths.

The treatment of pathologies of posterior segment of eye, such as chorioretinitis, uveitis, various neuroretinopathies, vitreous diseases, intraocular hemorrhage, is a rather serious problem due to the difficulties of the adequate delivery of preparations into area of pathological process. One of the most effective ways to deliver drugs to eye tissue in posterior segment are intravitreal injections. The introduction of drugs is carried out directly into vitreous body through a puncture of sclera. This article presents the indications for intravitreal injections, a detailed description of properties of numerous therapeutic agents that can be delivered through intravitreal injections, potential complications of this technique and recommendations for prevention of side effects.

The lens dislocation (ectopia) is a partial or complete lens displacment from the normal anatomical position to the anterior chamber of an eye or into the vitreous body due to a violation of the integrity of the Zinn ligaments that hold the lens in a normal position. There are two different methods for dislocated lenses removing ― the «open sky» surgery technique or the ultrasonic phacoemulsification. According to results and clinical analysis of the lens dislocation surgery in small pets we have identified that using the «open sky» surgery is the optimal method for lens dislocation surgery in the anterior chamber in aged cats and dogs or pets with severe somatic pathology. Our technique of surgery with performing diamond microsurgery is more efficient and perfect, requires much less time than phacoemulsification. It optimizes the stages of the operation, minimizes complications and significantly improves the results of operations.

Proptosis of the globe (luxatio bulbi oculi) is a traumatic displacement of the eyeball beyond the bone orbit. Globe proptosis is a fairly common emergency ophthalmic pathology among dogs and cats, which any doctor may encounter in his practice. Moreover, the outcome of the pathological condition depends both on the severity of the primary damage to the eye and on the correct algorithm for providing medical care to the patient. In this article we tried to answer the main ten questions: a clinical assessment of the severity of the condition, reposition and immibilization of the globe, methods to reduce intraorbital edema and the prevention of bacterial complications, that a veterinarion practitioner may have during his medical work with this severe pathology.