No abstract

Insulin resistance and overweight have been associated with major risk factors such as blood pressure (BP) for cardiovascular disease. In this study the effect of Nano-capsules of resveratrol (RV-NC) on BP control is evaluated. RV-NC nanoparticles were analyzed by SEM, Zeta sizer, Potentiometer and HPLC. The analysis resulted from RV-NC synthesis showed that the Nano capsules have characteristics such as size of 207 nm, zeta potential of-7.15 and loading effi ciency of 99.54% ± 1.02. BP reduction was associated with reduction of weight and enhance of QUICKI index which represents insulin resistance. RV-NC were prepared by interfacial deposition and then its applicability was evaluated in metabolic syndrome induces mice. The effect of RV-NC was studied on fourteen mice. Induction of syndrome by high fat diet and high BP was observed. The collected data were analyzed by ANOVA and Turkey criteria were used to compare the distinction between the groups. Finally, the results indicated that RV-NCtreated mice have regulated in systolic and diastolic blood pressure (compare to the other group (p< 0.05). The effective formulation of nano-capsules for resveratrol delivery not only can be helpful in increasing the in vivo stability, but also in regulation of the patient's blood pressure with at least cost of therapy.

The aim of this study is to evaluate the effect of resveratrol nanocapsules (RV-NCs) by quantitative insulin sensitivity check index (QUICKI) for insulin resistance diagnosis on metabolic syndrome induction in mice. Next, the applicability of these nanocapsules (NCs) was evaluated in metabolic syndrome induced in 40 mice. RV-NCs were synthesized by interfacial deposition method and was analyzed by various methods including Zetasizer, high-performance liquid chromatograph, potentiometer and scanning electron microscopy. The analysis results show a zeta potential of − 7.15, loading efficiency of 99.54 ± 1.02% and particle size of 207 nm for RV-NC production. Collected data from mice examination were analyzed by ANOVA and Tukey criteria. The validity and the reproducibility of the QUICKI index in a population of mice were determined and found that is a significant difference between high fat diet group and the control group (p < 0.05). In addition, the result obtained by the Tukey test indicated the difference in insuline and glucose levels of these group. Also, it probably is associated with the increase in the in vivo stability, which is obtained by the effective formulation of nanocapsules for resveratrol delivery.