дерматологии и венерологии НАМН Украины» 2 Украинская военно-медицинская академия Министерства обороны Украины 3 Научно-инженерный центр профессиональной лабораторной диагностики «Днепролаб» Резюме Цельгенотипирование T. vaginalis, обнаруживаемых у больных урогенитальной патологией в Украине. Материалы и методы. Проведено генотипирование T. vaginalis методом Crucitti T. et al. в 29 образцах, полученных у больных c с хронической урогенитальной патологией в северо-восточном и центральном регионах Украины. Результаты. Наиболее распространенным выявился генотип Е (68,9%), реже встречались генотипы G (20,7%), H (10,35%) и A (3,45%). Выводы. Наиболее распространенным генотипом T. vaginalis, циркулирующих в Украине, является генотип Е, значительно реже встречаются возбудители генотипов G, H и А. Не выявлено взаимосвязи генотипа с клиническими признаками заболевания.

No abstract

There are no accurate data regarding the prevalence of Chlamydia trachomatis infection in Ukraine. This study aims to estimate the prevalence in the northeastern region of the country through reviewing nucleic acid amplification test results in patients of medical institutions in the Kharkov region during 2014-2016. Samples from 6920 patients (5028 women and 1892 men) aged 12-76 years were tested. The overall positivity rate was 4.5% (95% CI 4.0-5.0): 3.9% (95% CI 3.4-4.5) in women and 6.1% (95% CI 5.1-7.3) in men. The highest prevalence was found in the 16-20 (8.5%, CI 6.3-11.4) and 21-25 (8.0%, CI 6.7-9.4) year age groups. The prevalence in men was higher than in women in all investigated groups. The results show the need for more attention to the prevention, diagnosis, and treatment of chlamydial infection in these age groups of women and men in this region.

Introduction: The paper presents the results of investigations of the skin’s barrier function in patients diagnosed with atopic dermatitis (AD) with the presence of one of the genetic predispositions, namely the filaggrin gene FLG 2284del4 mutation. The aim: to deepen the study of the relationship between the mutations of the gene FLG del2282 and the morphological features of the skin, since the data on its physiological state in patients diagnosed with AD are contradictory that will contribute to the improvement of the modern basis necessary for the development of treatment-diagnostic and preventive measures. Materials and methods: In the given study of patients diagnosed with AD (41 person), the frequency of the FLG 2282del4 gene deletion constituted 19.51% (8 patients) according to the method of Palmer et al. To determine the functional parameters of the skin in patients diagnosed with AD in the carriers of the FLG gene mutation and in patients void of this mutation, they have applied a multifunctional Aramo TS portable analyzer that enables to carry out dermatoscopic diagnosis of the skin surface. Results and conclusions: As a result of the analysis of the obtained physiological parameters of the skin in the patients of both groups during the treatment process, it is noteworthy that the dynamics of these indices after treatment in patients void of the filaggrin gene mutation is significantly better in comparison with the patients in whom the filaggrin 2282 del14 gene mutation was revealed. There is a tendency towards the decrease of skin’s moisture and elasticity in patients with revealed mutation compared with the ones who are void of it. Given this fact, the study of physiological parameters of the skin is important to consider when substantiating the diagnostic-treatment and prophylactic algorithm for patients diagnosed with AD.