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Mixtures of calf thymus DNA and the lysine-rich histone fraction, f-1, from the same tissue were examined under various conditions by means of circular dichroism. These DNA-histone complexes, which are a model system for chromatin, display conformational changes dependent upon solvent and upon complex composition and concentration. At moderate salt concentration (0.14 m NaF) the conservative circular dichroic spectrum of DNA becomes progressively distorted as increasing amounts of histone are added: the positive ellipticity band at 275 µ decreases, the negative band at 245 µ increases in magnitude, both bands are red * Publication No.

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