Background: Depression is a mental disorder that affects 279 million people. Patients with depression will not only have an impact on themselves but can also have an impact on others. Objective: Provide an overview of the impact of depression on health workers, workers, students and patients, as well as the prevention of depression. Methods: Data on the impact of depression and its prevention using the Google Scholar and Pubmed search engine. Results: Depression in healthcare workers can affect the occurrence of misdiagnosis of a patient's disease, reduce the quality of service, and increase the risk of suicide. Depression in other workers can result in lost productivity and income, absenteeism, presenteeism, and accidents in the workplace. Depression in students causes decreased student achievement, difficulties concentrating and social interactions, and absenteeism. In patients with physical illness, depression can increase the risk of mortality, re-hospitalization, higher costs, poor treatment adherence, and lost follow-up. Depression prevention can help lower the risk of depression by up to 21%. This prevention must be done as early as possible and starts from the scope of prevention at the family level. Then this prevention can be done individually, especially for those with a high risk of experiencing depression. The last prevention is universal prevention (population) which can be started by educating the community Conclusion: Depression can happen to anyone and will have a detrimental impact on themselves and others. Prevention of depression should be done as early as possible to prevent the impacts of depression.

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Background: Until now, cancer has become one of the main problem topics in the world of health. The incidence of this cancer is expected to continue to increase. One of the main risk factors that increase the risk of cancer is an unhealthy lifestyle in the form of alcohol consumption, unhealthy diet, smoking, and lack of physical activity. Objectives: This article provides an understanding of each unhealthy lifestyle pattern for the occurrence of cancer. Methods: The writing of this article uses the literature review method. Information is taken from e-book sources, websites, and search engines. Discussion: The initial process of cancer stems from genetic damage. If this genetic damage cannot be repaired, it can progress to cancer. Each pattern of unhealthy lifestyles has its own mechanism in triggering cancer. Conclusion: An unhealthy lifestyle can increase the risk of cancer. Keywords: cancer, life style, risk factor   Latar belakang: Sampai saat ini penyakit kanker menjadi salah satu topik permasalahan utama di dunia kesehatan.  Kejadian kanker ini diperkirakan akan terus mengalami peningkatan. Salah satu faktor risiko utama yang meningkatkan risiko terjadinya kanker adalah gaya hidup tidak sehat berupa konsumsi alkohol, diet tidak sehat, merokok, dan kurang aktivitas fisik. Tujuan: Artikel ini menjabarkan pemahaman mengenai masing-masing pola gaya hidup yang tidak sehat terhadap terjadinya kanker. Metode: Penulisan artikel ini menggunakan metode literature review. Informasi diambil dari sumber e-book, website, dan search engine. Pembahasan: Proses awal tercetusnya kanker bermula dari adanya kerusakan genetik. Apabila kerusakan genetik ini tidak dapat diperbaiki dapat berkembang menuju kanker. Setiap pola gaya hidup yang tidak sehat memiliki mekanismenya masing-masing dalam mencetuskan kanker. Kesimpulan: Gaya hidup tidak sehat dapat meningkatkan risiko terjadinya kanker. Kata Kunci: faktor risiko, gaya hidup, kanker

Background: When stress conditions can be the root of various diseases, one of which is Broken Heart Syndrome (BHS). It is estimated that 90% of cases of BHS occur in women who have entered postmenopause. The mortality from BHS cases is quite high, reaching 2-5% with the main cause of death due to cardiogenic shock and ventricular fibrillation. Objective: To provide the latest information about BHS from various literatures. Methods: Writing this article using a literature searching method. Search for articles using the help of search engines in the form of Google Scholar, Pubmed and Clinicalkey with articles that have been published in the last 10 years and in English. Discussion: Prolonged physical stress conditions can trigger BHS. Risk factors associated with BHS conditions include age over 55 years, smoking, excessive alcohol consumption, a history of anxiety and hyperlipidemia. Complications can occur in 52% of cases of BHS. Mortality in BHS cases tended to be higher in BHS cases that was triggered by physical factors than that triggered by emotional factors. Conclusion: BHS is a condition that occurs after emotional stress or physical stress, so controlling the stress triggers is expected to prevent the occurrence of BHS. Keywords: broken heart syndrome, stress, heart failure   Latar belakang: Kondisi stres saat dapat menjadi akar dari berbagai macam penyakit salah satunya Broken Heart Syndrome (BHS). Diperkirakan 90% kasus BHS terjadi pada perempuan yang sudah memasuki postmenopause. Mortalitas dari kasus BHS cukup tinggi yakni mencapai 2-5% dengan penyebab kematian utama dikarenakan shok kardiogenik dan ventrikular fibrilasi. Tujuan: Memberikan informasi terkini seputar BHS dari berbagai literatur. Metode: Penulisan artikel ini menggunakan metode literature searching. Pencarian artikel menggunakan bantuan mesin pencari berupa Google Scholar, Pubmed, dan Clinicalkey dengan artikel yang telah dipublikasikan dalam 10 tahun terakhir dan berbahasa Inggris. Pembahasan: Kondisi stres fisik yang berkepanjangan dapat mencetuskan BHS. Faktor risiko yang berkaitan dengan kondisi BHS berupa usia diatas 55 tahun, merokok, konsumsi alkohol berlebih, riwayat ansietas dan hiperlipidemia. Komplikasi dapat terjadi pada 52% kasus BHS. Mortalitas pada kasus BHS cenderung lebih tinggi pada kasus BHS yang dipicu oleh faktor fisik dibandingkan yang dipicu oleh faktor emosi. Kesimpulan: BHS ini adalah kondisi yang timbul pasca stres emosional atau fisik sehingga dengan mengendalikan faktor pencetus stres ini diharapkan dapat mencegah terjadinya BHS. Kata Kunci: broken heart syndrome, stres, gagal jantung