These data can be used to update cost analyses of mammography screening that wish to take into account the QOL impact of screening.

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185HMORN 2012 -Selected Abstracts environmental change strategies. To help evaluate the impact of these initiatives we have created a measure of estimated strategy-level impact that we refer to as 'population dose' that provides an overall estimate of the impact of a strategy on food and physical activity behaviors. We provide a definition and examples of measuring population dose and show how the concept was used in an evaluation of the Kaiser Permanente's Healthy Eating, Active Living Community Health Initiative in Northern California (HEAL-CHI). Methods: HEAL-CHI was a community initiative designed to reduce obesity by implementing community-and organizational-level policy and environmental changes in three low-income communities in Northern California. Population dose was defined as the product of reach (number of people exposed to an intervention strategy) and strength (change in behavior for each person reached). Since quantitative effect sizes for policy and environmental change interventions are generally unavailable, we used a three-level rating system to assess the strength of each intervention strategy, combining evaluation results with estimates of intensity. We then examined data from youth surveys to assess whether population-level changes from the youth surveys were greater where high-dose strategies were present. Results: The HEAL-CHI population-level results were inconclusive overall, but showed positive and significant findings for four of the nine youth survey comparisons where "high dose" strategies were implemented, primarily physical activity interventions targeting elementary and middle school-age youth. For example, the percent of children reporting exercising at least 20 minutes per day increased from 61% to 67% in a community implementing a high-dose after-school physical activity program, a statistically significant (p<.05) increase relative to comparison schools. Discussion: The concept of population dose provides a way of comparing the potential community impact of different obesity prevention strategies and combining the estimates from multiple strategies to get an estimate of cumulative impact. In addition, we found that for the HEAL-CHI communities where there were high dose strategies in place there were a number of significant and positive populationlevel behavior changes. Background/Aims: Weight gain is an undesirable side effect of treatment with 2nd/3rd generation antipsychotic drugs which may have genetic determinants. A number of candidate genes have been analyzed but no genome-wide association studies (GWAS) have yet been reported. The purpose of this study was to determine the rate of extreme weight gain (EWG) among adult users of 2nd/3rd generation antipsychotic medications for future GWAS. Methods: A standardized dataset was extracted on antipsychotic medications users at Group Health and Geisinger Health System from 2004-2010 that included demographics, enrollment, vitals, and pharmacy data. Electronic health record search algorithms were used to identify adult subject...