Mycoplasma pneumoniae-associated mucositis is a rarely described complication of M. pneumoniae infection presenting with ocular, oral, and genital involvement but without the typical skin lesions seen in Stevens-Johnson syndrome. A 27-year-old man with a past history of asthma presented at the emergency room with a 1-week history of cough (initially non-productive but subsequently associated with non-bloody mucopurulent sputum), fever, myalgias, headache, and progressive dyspnea. Two days before admission he had commenced amoxicillin/clavulanic acid with no improvement. The patient reported bilateral conjunctival injection and hemorrhagic ulcers on the lips commencing the day prior to admission. Physical examination revealed fever (39 degrees C), bilateral exudative conjunctivitis, painful hemorrhagic ulcers on the lips, tongue, and oral mucosa, small scrotal erosions, erythema of the penile meatus, and small erythematous bullae on the dorsum of each hand; subsequently, the patient developed bullae at the venipuncture site on his right arm. Laboratory tests revealed positive IgM serology for M. pneumoniae, with titer elevation. The patient was successfully treated with levofloxacin and prednisolone. Our case appears to be the first adult patient described with M. pneumoniae-associated mucositis, which has previously been reported only in pediatric patients. This is also the first reported instance of a case of M. pneumoniae-associated mucositis treated with levofloxacin and prednisolone. M. pneumoniae infection should be considered in all cases of mucositis, and treatment of this condition with levofloxacin and prednisolone seems to be effective.

e235 otics, Piperacillin/Tazobactam was most commonly used (23 cases, 33.8%) and Cefepime was next. (20 cases, 29.4%). Successful response to initial antibiotics was 5 cases (72.4%) in MDI, 30 cases (85.7%) in CDI, and 24 cases (92.3%) in UF. Mortality rate was 4.4% and all death was related to infection. Conclusion: There were no evident differences of clinical features between the 1st period and the 2nd period. But we found two specific clinical features. The rate of successful response to initial antibiotics was the highest in UF (92.3%). It means that we need to change or add the empirical antibiotics if we could guess the site of infection rather than use the recommended antibiotics in 2002 IDSA guidelines. And extremely high portion of gram-positive bacteria (85.7%) were isolated compared with other clinics in Korea. We think it might be an unique clinical feature in Jeju island. In the future, empirical antibiotics that cover the grampositive bacteria for NF may need to be routinely used in Jeju island.