Uvod: Alergija je neuspešan odgovor organizma protiv stranih antigena. Ponovno uvođenje iste strane materije u organizam izaziva reakciju koja dovodi do uništavanja sopstvenog tkiva. Alergijske reakcije se mogu izraziti u različitim organima i u bilo kojoj starosnoj grupi. Materijal i metode: U ovom radu učestvovalo je 84 pacijenta. Dijagnoza je zasnovana na pozitivnoj anamnezi preordiniranja leka, ugriza insekata, ranijih alergijskih reakcija, kao i tipične kliničke slike. Pratile su se varijante alergijskih promena , kao i najčešći uzroci njihove pojave. U potrazi za najčešćim alergenima, lekovi u stomatološkoj praksi takođe su smatrani potencijalnim pokretačima alergijskih događaja. Rezultati: Najčešći oblik alergijske reakcije bio je Stomatitis allergica i Enanthema fixum, sa lokalizacijom na dorzalnoj površini jezika i sluzokožom obraza. Skoro polovina registrovanih pacijenata prijavila je promenu nakon uzimanja odgovarajućeg leka iz grupe sulfonamida i penicilina. Zaključak: Ako je uzrok alergija poznat, prevencija kontrole alergijske reakcije je na prvom mestu. Visoka prevalenca alergijskih bolesti, poboljšane dijagnostičke procedure i tretmani imali su veliki uticaj na pružanje medicinske zaštite pacijentima sa alergijom. Ponekad možda neće biti moguće potpuno izbeći alergijsku reakciju , ali ovi koraci mogu pomoći u sprečavanju budućih alergijskih reakcija. Lekari treba da usvoje jasne nazive alergijskih poremećaja i pridržavaju se nomenklature u njihovoj profesionalnoj i javnoj komunikaciji.

Introduction: Some of the typical skin diseases, such as Pemphigus vulgaris, Pemphigoid mucosae oris, Erythema exudativum multiforme, Sclerodremia, Dermatitis herpetiformis-Duhring and Lichen planus, can cause swelling and irritation in mucous membranes of the oral cavity. Aim: The aim of the study was to precise diagnosis and treatment of oral Lichen planus manifestations. Methods: Analyzing the literature data and the experience of clinicians, the most common oral lichen planus manifestations were investigated. Results: This disease most commonly occurs in middle-aged patients (30-60 years) and is more common in women than in men. Oral Lichen planus is rarely seen in children. The disease presents in 0.5% to 2% of the population. Clinical history established the relation between oral Lichen planus and oral carcinoma, and therefore this disease should be considered a precancerous lesion. Conclusion: Dermatoses in the mouth are localized most often in the oral mucosa, both at the height of the occlusal line and in the mucous membrane of the retromolar area, but they can also occur in the mucous membranes of the tongue, the floor of the mouth and lips.

Introduction: Diabetes mellitus (DM) is a chronic metabolic disorder and the high level of blood glucose has profound effects on various systems of the human body. DM increases the risk of periodontal disease and the severe periodontal disease often coexists in diabetic patients with poor glycemic control. The aim of the study was to analyse periodontal health in patients with diabetes mellitus type 2 related to diabetic complications and glycohemoglobin A1c values. Methodology: One hundred patients with periodontitis and type 2 DM participated in the study. According to the glycohemoglobin A1c value they were divided in 4 groups: group 1 (4%-6% normal), group 2 (6.1%-7% good), group 3 (7.1%-8% moderately poor), group 4 (> 8% poor metabolic control). The presence of chronic systemic microvascular diabetic complications (retinopathy, nephropathy and neuropathy) was recorded and periodontal assessments (Plaque, Gingival, Calculus and Periodontal Disease Index) performed. The results were statistically analysed using MS Office Excel, program SPSS, 15.0 version. Results: Gingival index values depended on the level of HbA1c values and higher values of the Gingival and Periodontal Disease Index were noticed as the value of glycohemoglobin A1c was rising (p<0,001). Gingival index values were higher in diabetics with diabetic chronic microvascular complications (p<0.001). Conclusion: It is observed that pronounced gingival inflammation in diabetics is associated with systemic diabetic complications and poor glycemic control.

Introduction: Recurrent aphthous stomatitis (RAS) is one of the most usual inflammatory diseases of the oral mucosa. The clinical characteristics of RAS are well defined, but the exact etiology and pathogenesis of the disease are not. Several investigations have noticed cigarette smoking to have a protective effect on RAS. The aim of the study is to investigate the association between cigarette smoking and RAS in order to improve the current knowledge on this issue. Methodology: 68 patients with RAS participated in the study. A full mouth clinical examination was performed and a medical history was taken for each patient. Data were analyzed with χ 2 test. Results: While 6 (8.9%) of patients with RAS were smokers, a significantly higher percentage (24.9%) among the subjects with RAS were not smokers (group II) (χ2 =70.4; d.f. = 2, P < 0.001). Conclusion: The negative association between smoking and RAS indicated by this investigation is not meant to encourage people to smoke nor to spare them from the intention to quit their habit. These conclusions should be used to clear up the cause and pathogenesis of the RAS and to identify better prevention and treatment.

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