Objectives The use of local probiotics in the therapy of periodontitis is reflected in their ability to antagonize periodontopathogens and modulates the immune response of the host to the presence of pathogenic microorganisms. The aim of this study was to investigate the use of local probiotics in the treatment of periodontitis as an adjunctive therapy to scaling and root planning (SRP). Methods The study involved 80 patients diagnosed with periodontitis. All participants underwent SRP therapy. Semi‐solid probiotic was then locally applied to the periodontal pocket in randomly selected patients for the test group (40 of them). The other 40 patients were in the control group. Clinical parameters including periodontal pocket depth (PPD), bleeding on probing (BOP) and plaque index (PI) were measured at baseline, and at 7 and 30 days after treatment. Results Seven days after the applied therapy in the test and control group, there was a significant decrease in the values or BOP (p < .001), while the values of other parameters did not show a statistically significant difference (p < .05). One month after the therapy in both groups, there was a statistically significant difference in the values of all clinical parameters (p < .001). Conclusions Based on the results of this pilot study, it can be said that, during periodontal treatment, topical application of probiotics in combination with SRP increases the effectiveness of conventional non‐surgical therapy of periodontitis.

Kvalitet života u vezi sa oralnim zdravljem je važna mera bolesti i samih ishoda terapijskih intervencija. Parodontopatija je inflamatorno oboljenje koje je povezano sa opštim stanjem pacijenta i negativno utiče na kvalitet života. Cilj ovog istraživanja bio je da se ispita efekat bazične terapije parodontopatije na kvalitet života kod pacijenata starijeg doba sa hroničnom parodontopatijom. Materijali i metode: Pacijenti sa parodontopatijom nasumice su raspoređeni u studijsku grupu (n=44) kod kojih je sprovedena bazična terapija,i kontrolnu grupu (n=44), koja nije primila nikakav tretman. Protokol je uključivao popunjavanje upitnika OHIP-14, pre i mesec dana posle tretmana, klinički pregled i bazičnu terapiju parodontopatije. Pacijenti su popunili i dodatna pitanja o zdravlju gingive kao i uticaju parodontopatije na kvalitet života. Rezultati: Rezultati kliničkih parodontalnih parametara nisu pokazali signifikantnu razliku među grupama na početku ispitivanja. Na kontroli je zabeleženo poboljšanje svih kliničkih parametara i signifikantna razlika između ispitivanih grupa (p<0,05), kao i u tretiranoj grupi pre i posle tretmana (p<0,001). Statistički značajne promene (p<0,001) u tretiranoj grupi zabeležene su za impakciju hrane, izbegavanje unosa određene vrste hrane, loš zadah, izbegavanje smejanja i prisustvo apscesa. Zdravlje gingive ocenjeno je sa "loše" ili "veoma loše" kod 42,73% ispitanika. Uticaj parodontopatije na svakodnevne aktivnosti kod pacijenata izražen je sa "često" ili "uvek" kada se smatralo da imaju najčešće probleme vezane za ove aktivnosti. Zaključak: Bazična tarapija parodontopatije značajno je uticala na kvalitet života pacijenata starijeg doba sa hroničnom parodontopatijom. Utvrđene su značajne razlike između odgovora pre i posle tretmana. U ovoj studiji uočen je prihvaćeni stepen svesti o problemima oralnog zdravlja u vezi sa parodontalnom bolešću kod pacijenata starijeg doba.

Introduction: Recent studies have found that patients with periodontitis have greater risk of incurring fatal cardiovascular disease than patients without periodontitis. Emerging research has identified inflammation caused by periodontitis as significantly increasing the risk for ACS. Aim: The aim of this study was to investigate a periodontal status in the patients with ACS, and to assess the association of different periodontal parameters with ACS. Material and methods: In the first group, patients both with ACS and periodontitis were enrolled as cases. Patients were examined 3 days after ischemia. The second group consisted of patients who had only periodontitis. The control group consisted of healthy individuals. Periodontal parameters were measured and matched on the basis of demographic characteristics and assessed between the groups. The severity of periodontitis in both cases was analyzed. Results: Analysis of the periodontal parameters showed that median scores were higher in patients in the first and the second group compared to the third control group but significantly higher in group with ACS. Levels of inflammatory markers were highest in the first group, compared to the second group and the control group. Periodontal pathogens were more strongly present in patients with ACS than in the group with periodontitis, indicating that it was a serious illness in these patients. Conclusion: This study supports an association between periodontitis and ACS. Severe periodontitis is present in this patients indicating that periodontitis can further act on the development of ACS.

Introduction: Some of the typical skin diseases, such as Pemphigus vulgaris, Pemphigoid mucosae oris, Erythema exudativum multiforme, Sclerodremia, Dermatitis herpetiformis-Duhring and Lichen planus, can cause swelling and irritation in mucous membranes of the oral cavity. Aim: The aim of the study was to precise diagnosis and treatment of oral Lichen planus manifestations. Methods: Analyzing the literature data and the experience of clinicians, the most common oral lichen planus manifestations were investigated. Results: This disease most commonly occurs in middle-aged patients (30-60 years) and is more common in women than in men. Oral Lichen planus is rarely seen in children. The disease presents in 0.5% to 2% of the population. Clinical history established the relation between oral Lichen planus and oral carcinoma, and therefore this disease should be considered a precancerous lesion. Conclusion: Dermatoses in the mouth are localized most often in the oral mucosa, both at the height of the occlusal line and in the mucous membrane of the retromolar area, but they can also occur in the mucous membranes of the tongue, the floor of the mouth and lips.

Objectives Chronic periodontal infections may predispose to cardiovascular disease. Since tooth loss may be due to periodontitis it is assumed that tooth loss can also predisposes cardiovascular disease. The aim was to investigate the possible relationship between the severity of the clinical picture of periodontitis and the occurrence of cardiovascular disease. Methods We evaluated the association between clinical periodontal parameters, tooth loss and cardiovascular incident. A total of 100 subjects (50 subjects diagnosed with cardiovascular disease and 50 in control group without cardiovascular disease) underwent a dental examination. Tooth loss in all participants was caused only as a consequence of periodontitis. In addition to periodontal status, conventional risk factors for cardiovascular diseases (hypertension, smoking, obesity, hypercholesterolemia, diabetes) were measured, too. Results Periodontal status was worse in patients in the group with cardiovascular disease compared to the group without cardiovascular disease. A significant association was observed between tooth loss levels and cardiovascular disease. In the group of patients who had cardiovascular disease, tooth loss was more than 50%. In the group of patients without cardiovascular disease, tooth loss was about 20% of the total number of teeth. A significant association was observed between tooth loss levels and cardiovascular disease prevalence. Conclusion This study presents relationship between number of teeth and cardiovascular disease, indicating a link between oral health and cardiovascular disease.