Some clusters of children with a multisystem inflammatory syndrome associated with SARS-CoV-2 infection (MIS-C) have been reported. We describe the epidemiological and clinical features of children with MIS-C in Spain. MIS-C is a potentially severe condition that presents in children with recent SARS-CoV-2 infection.

Background: COVID-19 has reached more than 20 million people since its appearance in December 2019. As a result of the infection process by the Sars-CoV-2 virus, patients manifest initial symptoms easily mistaken for common flu. However, in a small group of the population, the condition may progress to pneumonia or Severe Acute Respiratory Syndrome (SARS). Objective: The objective of this study was to carry out an integrative review on laboratory and imaging diagnostics for COVID-19, in the period from 2019 to 2021. Method: Electronic databases PubMed, Google Scholar, SciELO, Virtual Library, LILACS, MEDLINE, ScienceDirect and the official website of the World Health Organization were used. Results: RT-qPCR identifies fragments of viral RNA in the initial stage of the disease since the genes E and RdRp are the most used, given the great sensitivity. Imaging and serological methods can be used as complementary exams. The main radiographic findings are reticular and ground-glass opacity patterns, reversed halo sign, mosaic attenuation, and consolidations. The antibody levels are detected after the seventh day of symptom onset. Conclusion: Caution should be exercised when interpreting the results for the diagnosis of COVID-19, since the onset of clinical symptoms and laboratory and imaging tests must be taken into account.

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