Three studies assessed changes in the content, consensus, and favorableness of 10 ethnic and national stereotypes by replicating and extending the Princeton trilogy. Results indicated that throughout the past 60 years, almost all of the ethnic and national stereotypes that were examined had changed in content, and more than half had changed in consensus. Most changes in consensus reflected increases rather than decreases, suggesting that modern members of stereotyped groups may confront stereotypes more frequently than did previous members of stereotyped groups. However, the damaging effects that consensual stereotypes can have on members of these groups may be tempered by the finding that most of the stereotypes became more favorable. These results are discussed in terms of changing social roles, intergroup contact, and stereotype accuracy.

Adenomyoepithelioma of the breast is a rare tumor characterized by epithelial−myoepithelial differentiation, whose genetic underpinning is largely unknown. Here we show through whole-exome and targeted massively parallel sequencing analysis that whilst estrogen receptor (ER)-positive adenomyoepitheliomas display PIK3CA or AKT1 activating mutations, ER-negative adenomyoepitheliomas harbor highly recurrent codon Q61 HRAS hotspot mutations, which co-occur with PIK3CA or PIK3R1 mutations. In two- and three-dimensional cell culture models, forced expression of HRASQ61R in non-malignant ER-negative breast epithelial cells with or without a PIK3CAH1047R somatic knock-in results in transformation and the acquisition of the cardinal features of adenomyoepitheliomas, including the expression of myoepithelial markers, a reduction in E-cadherin expression, and an increase in AKT signaling. Our results demonstrate that adenomyoepitheliomas are genetically heterogeneous, and qualify mutations in HRAS, a gene whose mutations are vanishingly rare in common-type breast cancers, as likely drivers of ER-negative adenomyoepitheliomas.

Treatment of CSOM with aural toilet and topical antibiotics, particularly quinolones, is effective in resolving otorrhea and eradicating bacteria from the middle ear. Longterm outcomes such as preventing recurrences, closure of tympanic perforation and hearing improvement need to be further evaluated.

Objective. To provide the first population-based data on deafness and hearing impairment (OR = 12.55;

TSH suppression significantly increases the risk of postoperative osteoporosis without changing tumor recurrence in ATA low- and intermediate-risk patients with DTC. Future interventions should focus on avoiding harm in indolent disease.