Hepatocellular carcinoma is one of the leading malignancies worldwide. Early detection of hepatocellular carcinoma and its management in the form of liver transplantation offers an attractive treatment option. The Milan criteria, proposed by Mazzaferro et al, have been the standard for selecting patients with hepatocellular carcinoma for transplantation. Recently, several studies have shown that even patients selected outside the Milan criteria can undergo transplantation with a relatively good outcome. This article examines the currently existing criteria other than the Milan criteria and also evaluates use of alpha-fetoprotein and positron emission tomography scans to predict the chance of recurrence.

lncRNAs forms a part of the non coding part of human genome. This term denotes specific non coding RNAs with nucleotide length more than 200. They have been shown to affect various physiological and pathological processes within the human body. Of interest is their role in malignant transformation in several cancers. In this review, the role of lncRNAs in GI cancers namely pancreatic cancer, gastric cancer, hepatocellular cancer and colorectal cancer have been explained in brief. These lncRNAs have shown to be useful as a marker for detection and prognosis of various malignancies. They also have shown to have therapeutic potential. Various relevant lncRNAs in each section has also been mentioned. [3]. Non coding RNAs with length more than 200 nt have been termed as long non coding RNAs. Recent studies using microarray technologies have shown that lncRNAs play an important role in several aspects of malignancies. In this How to cite this paper: KrishnaJournal of Cancer Therapy lncRNAs are known to affect diverse processes within the cell. An idea of function can be made based on its subcellular localization [8]. It can be subnuclear, cytoplasmic or both [9] [10]. lncRNA in nuclear position usually affect nuclear function via transcriptional or epigenetic modifications [11] [12] [13]and cytoplasmic lncRNA modulates mRNA stability and translation [13] [14].