Role of lncRNAs in GI Cancer

Abstract

lncRNAs forms a part of the non coding part of human genome. This term denotes specific non coding RNAs with nucleotide length more than 200. They have been shown to affect various physiological and pathological processes within the human body. Of interest is their role in malignant transformation in several cancers. In this review, the role of lncRNAs in GI cancers namely pancreatic cancer, gastric cancer, hepatocellular cancer and colorectal cancer have been explained in brief. These lncRNAs have shown to be useful as a marker for detection and prognosis of various malignancies. They also have shown to have therapeutic potential. Various relevant lncRNAs in each section has also been mentioned. [3]. Non coding RNAs with length more than 200 nt have been termed as long non coding RNAs. Recent studies using microarray technologies have shown that lncRNAs play an important role in several aspects of malignancies. In this How to cite this paper: KrishnaJournal of Cancer Therapy lncRNAs are known to affect diverse processes within the cell. An idea of function can be made based on its subcellular localization [8]. It can be subnuclear, cytoplasmic or both [9] [10]. lncRNA in nuclear position usually affect nuclear function via transcriptional or epigenetic modifications [11] [12] [13]and cytoplasmic lncRNA modulates mRNA stability and translation [13] [14].

Hepatocellular carcinoma – time to take the ticket

“…Ultimately, all of these protocols and criteria were created because we do not have a complete understanding of the genetic alterations that lead to carcinogenesis and the way that different mutations affect cancer biology. In the future, having a better understanding of the genetic makeup of tumors and using new markers, such as long noncoding RNAs[27], can make these criteria obsolete. Until then, we can strive to achieve the best result possible without causing harm to other patients.…”