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This study provides clinically important information on the stability of meropenem and PIP/TZB, each in combination with heparin, in different PD solutions. The use of meropenem-heparin admixed in pH-neutral PD solutions for the treatment of PDAP should be avoided, given the observed suboptimal stability of meropenem.

A vast population of the world is vulnerable to fluoride contaminated drinking water intake, and there are various defluoridation techniques available to date as well. But the removal of fluoride is still a challenge, especially in remote rural areas because available techniques require proper supervision and equally, ineffective due to economic issues and electricity crisis. Among all methods of defluoridation, adsorption methods are found better to carry out at the community and household level but sometimes demanded a replacement of commercial activated carbon (CAC) due to economic issues and less availability in remote areas. Hence keeping this in mind, the present study assessed the pine cone activated carbon (PCAC) as adsorbent material in the defluoridation that is easy to prepare like any other agriculture-waste material. The activated carbon was prepared using KOH as an impregnating agent for activation of pine cone by pyrolysis technique at 800 °C and has been analyzed for various parameters in the fluoride removal viz. contact time, dose variation, pH and initial fluoride concentration. The maximum adsorption capacity of fluoride on pine cone activated carbon was found 1.34 mg/g of initial fluoride concentration (2-12 mg/L) at pH (6.8-7.0) with a contact period of 45 min. Also, a comparison has been made between Pine Cone Activated Carbon (PCAC) with Commercial Activated Carbon (CAC) based on obtained results. It has been suggested that Pine cone activated carbon is efficient as well as cheap adsorbent and can be used for the removal of fluoride from drinking water in rural areas.

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