The reliable identification of the irritative zone (IZ) is a prerequisite for the correct clinical evaluation of medically refractory patients affected by epilepsy. Given the complexity of MEG data, visual analysis of epileptiform neurophysiological activity is highly time consuming and might leave clinically relevant information undetected. We recorded and analyzed the interictal activity from seven patients affected by epilepsy (Vectorview Neuromag), who successfully underwent epilepsy surgery (Engel > = II). We visually marked and localized characteristic epileptiform activity (VIS). We implemented a two-stage pipeline for the detection of interictal spikes and the delineation of the IZ. First, we detected candidate events from peaky ICA components, and then clustered events around spatio-temporal patterns identified by convolutional sparse coding. We used the average of clustered events to create IZ maps computed at the amplitude peak (PEAK), and at the 50% of the peak ascending slope (SLOPE). We validated our approach by computing the distance of the estimated IZ (VIS, SLOPE and PEAK) from the border of the surgically resected area (RA). We identified 25 spatiotemporal patterns mimicking the underlying interictal activity (3.6 clusters/patient). Each cluster was populated on average by 22.1 [15.0–31.0] spikes. The predicted IZ maps had an average distance from the resection margin of 8.4 ± 9.3 mm for visual analysis, 12.0 ± 16.5 mm for SLOPE and 22.7 ±. 16.4 mm for PEAK. The consideration of the source spread at the ascending slope provided an IZ closer to RA and resembled the analysis of an expert observer. We validated here the performance of a data-driven approach for the automated detection of interictal spikes and delineation of the IZ. This computational framework provides the basis for reproducible and bias-free analysis of MEG recordings in epilepsy.

The article presents the results of a study of life meanings and values in connection with the life satisfaction of persons with drug addiction at the stage of rehabilitation. The urgency of the problem is determined by the fact that the statistics provided by the UN confirm that the number of people who use drugs is steadily increasing every year. In this regard, the issues of prevention of drug addiction and rehabilitation of addicts for the Russian society are today the most acute and represent a global problem. The results obtained in the study state that for drug addicts at the stage of rehabilitation, they begin to have a meaningful attitude to their life, positively assess the life path they have passed and the experience gained, considering it the beginning of a new stage in life, and make plans for the future. This fact may indicate the productivity of the rehabilitation program. They do not think about how much life in general is subject to control on their part. The respondents attach value to the very living of life, feel the need to be able to feel love in all its manifestations. Status and altruistic meanings are of the least importance in the respondents' system of life meanings. Hedonistic meanings of life prevail, acceptance of life as it is. Also, statistically significant relationships were found between the components of life meanings and values and the components of life satisfaction in drug addicts.

The article focuses on the importance of educational mentoring for older adolescent orphans that involves community-minded non-profit organizations. The authors have sufficiently substantiated and developed a technology of educational mentoring for orphans of school leaving age to be applied in centres for helping childreninvolving representatives of community-minded non-profit organizations in order to form the orphans’ skills and competencies necessary for living on their own, increase their level of hardiness and actualize the value and moral contexts. The effectiveness of the developed technology is ensured by the creation of such a pedagogical space in which, in the interaction of employees of the center for helping children and mentors-volunteers of a non-profit organization, a huge impact is made on the indicators of the formation of personal characteristics of the resilience of graduates and, in the future, on the results of their social adaptation and integration in society. The author comes to the conclusion that the system of pedagogical mentoring of orphans allows to increase the level of their social adaptation. The indicators of this technology are the spiritual and moral values inherent in the Russian family, and the mentoring technology is a pedagogical tool for the formation of model characteristics of a resilient graduate in orphans.

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The modern social environment in general, and educational in particular, imposes a number of requirements on the personality of the student as a future representative of the professional community. This manifests itself in the need to master professional knowledge and skills in the conditions of constantly changing requirements, planning their activities for the short and / or long term, as well as multiple flexibility of behavior. The object of the research was 100 students of various faculties of DSTU (technical and humanitarian orientation). In the course of the empirical study, we used diagnostic methods for identifying self-regulation mechanisms in the student environment "USK" by J. Rotter; a questionnaire for the diagnosis of individual stylistic features of self-regulation (V. I. Morosanova), the methodology “Research of volitional self-regulation” (A. V. Zverkova, E. V. Eydman). The practical significance of the work lies in the subsequent use of the data obtained in the framework of psychocorrectional work with students of the organization of secondary vocational education.