In response to infection, macrophages adapt their metabolism rapidly to enhance glycolysis and fuel specialized antimicrobial effector functions. Here we show that fungal melanin is an essential molecule required for the metabolic rewiring of macrophages during infection with the fungal pathogen Aspergillus fumigatus. Using pharmacological and genetic tools, we reveal a molecular link between calcium sequestration by melanin inside the phagosome and induction of glycolysis required for efficient innate immune responses. By remodeling the intracellular calcium machinery and impairing signaling via calmodulin, melanin drives an immunometabolic signaling axis towards glycolysis with activation of hypoxia-inducible factor 1 subunit alpha (HIF-1α) and phagosomal recruitment of mammalian target of rapamycin (mTOR). These data demonstrate a pivotal mechanism in the immunometabolic regulation of macrophages during fungal infection and highlight the metabolic repurposing of immune cells as a potential therapeutic strategy.

Objective: to describe the validation of the booklet on self-care with the feet of people with diabetes. Method: methodological study, focusing on the validation of a printed booklet. The content and appearance of the booklet was validated by 23 judges divided into three groups: 11 content and appearance, seven technicians and five of the area of design and marketing. The appearance was validated by 30 people with type 2 Diabetes Mellitus. Results: the judges in the nursing area allowed the validation of material with a Content Validity Index (CVI) of 0.99, judges in the area of design and marketing with Suitability Assessment of Materials (SAM) of 99.2% and the target audience with concordance index of 99.4%. Conclusion: the educational booklet proved to be valid and reliable educational material to be used in order to promote compliance with self-care with the feet of people with Diabetes Mellitus.

RESUMOIncontinência urinária é um problema de saúde pública por ser uma doença multifatorial que acomete, em termos, 27,6% das mulheres e 10,5% dos homens, refl etindo nas relações interpessoais, profi ssionais e sexuais. O estudo teve como objetivo caracterizar o perfi l sociodemográfi co, epidemiológico e clínico de mulheres com incontinência uriná-ria atendidas em uma clínica ginecológica de um hospital universitário do Piauí. É uma pesquisa de campo do tipo exploratório descritiva e transversal, que foi realizada em setembro de 2015, mediante a aplicação de um formulário semiestruturado a 48 mulheres. A prevalência de incontinência urinária foi maior em mulheres com faixa etária entre 30 e 48 anos (52,1%), casadas (56,3%), pardas (72,9%) e com ensino fundamental incompleto (39,6%). Destacam-se como fatores de risco: consumo de cafeína (97,9%), cirurgia ginecológica (87,5%), infecção urinária (62,5%) e prática de atividade física (56,3%). O tempo de início da doença foi entre um e cinco anos (43,8%), com episódios de perda de urina ao espirrar (89,6%), ao tossir (83,3%) e antes de chegar ao banheiro (75%). Tais mulheres adotaram como atitudes comportamentais fi car próximas ao banheiro (54,2%) e fazer uso de absorventes ou de forros (41,7%). Apenas 33,3% procuraram um médico, 35,4% receberam orientações sobre a doença, 25% conheceram o diagnóstico médico e 12,5% realizaram algum tipo de tratamento. O estudo possibilitou conhecer a realidade das mulheres com incontinência urinária que buscam assistência à saúde em um hospital universitário, com resultados que se aproximam de estudos anteriores sobre a temática. DESCRITORES: Incontinência urinária. Fatores de risco. Enfermagem. Estomaterapia. ABSTRACTUrinary incontinence is a public health problem because it is a multifactorial disease that aff ects 27.6% of women and 10.5% of men. Thus, it refl ect in interpersonal, professional and sexual relations. The study aimed at characterizing the sociodemographic, clinical and epidemiological profi le of women with urinary incontinence cared at a gynecological clinic of a university hospital in Piauí, Brazil. It is a descriptive exploratory fi eld research, carried out in September 2015, by applying a semi-structured form in 48 women. The prevalence of urinary incontinence was higher in women aged between 30 and 48 years old (52.1%), married (56.3%), brown (72.9%) and with incomplete primary school educational

Similar efficacy with omalizumab in chronic idiopathic/spontaneous urticaria despite different background therapy.

ABSTRACT Objectives: to assess the usability of an app prototype for diabetic foot self-care by an end user. Methods: a descriptive study that uses heuristic assessment of a hybrid app usability. Fifteen users of an outpatient diabetes care service in a capital of Northeastern Brazil participated in the study during April 2018. The usability measurement tool called Smartphone Usability questionnaiRE was applied. Results: the lowest score was 77 and the highest was 112, with an average usability of 96.1 points. Usability was framed in the last two levels, 70 and 8o. Users now strongly agree (level 70) and fully (level 80) with the assessed items, which represents good usability of the apps prototype. Conclusions: the final product developed focuses on user needs and requirements, which can ensure usability based on effectiveness, efficiency and satisfaction triad.