Diffuse large B-cell lymphoma (DLBCL) is one of the B-cell large cell types of non-Hodgkin lymphoma (NHL) that has poor prognosis with highly variable clinical course. Various prognostic factors have been proposed to predict this, but the results were variable. C-MYC is a proto-oncogen that can cause overexpression leading to the increased of tumor cells proliferation. BAX is a main proapoptotic member of the BCL-2 family proteins that regulates apoptotic function. The study aimed to analyze correlation of c-MYC and BAX protein with various Ann Arbor stages in B-cell large cell type of NHL. This cross-sectional study was performed on 39 formalin fixed paraffin-embedded tissue of patients diagnosed as B-cell large cell type of NHL during January 2017 - December 2019 in Anatomical Pathology Laboratory at Dr. Soetomo General Hospital, Surabaya. To assess the expression of c-MYC and BAX, the immunohistochemistry examination was performed. Immunoexpression of C-MYC and BAX were evaluated according to the number of positive tumor cells divided by the total number of tumor cells and calculated in percentage. There was no difference in C-MYC (p = 0.877) and BAX (p = 0.093) expression with various Ann Arbor stages in B-cell large cell type of NHL. There was no correlation between c-MYC with BAX expression in various Ann Arbor stages in B-cell large cell type of NHL (rs = 0.206, p = 0.209). This indicated that C-MYC and BAX expression alone could not to be used as parameters to predict the outcome of the B-cell large cell type of NHL via Ann Arbor stages.

Inflammatory bowel diseases (IBDs) are chronic inflammatory diseases that often relapse and divided into two types, Crohn’s disease (CD) and ulcerative colitis (UC). Histopathological findings in colonic mucosal biopsy with clinical diagnosis suspicious IBD can vary and overlap. Therefore, criteria and guidelines have been created to improve the diagnostic accuracy. This descriptive observational study was performed retrospectively with cross sectional approach. 122 samples of colonic mucosal biopsies with clinical diagnosis of suspicious IBD were retrieved from histopathological archives in the Anatomical Pathology Laboratorium of Dr. Soetomo Hospital, Surabaya during period 1st January 2015 - 31st December 2019. The most common histopathological feature found in colonic mucosal biopsies with clinical diagnosis of suspicious IBD was crypt distortion (97/79.50% samples), and the least was irregularity of surface epithelium (30/24.59% samples). 10 of 122 samples was concordant with the final diagnosis of IBD. Knowledges regarding the variations of histopathological features in colonic mucosal biopsy specimens with clinical diagnosis of suspicious IBD, can improve the diagnostic accuracy.