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The present work describes the formulation, characterization and preliminary in vitro drug release studies of a thermoresponsive in situ gel containing gallic acid-loaded chitosan nanoparticles (CGNPs). Chitosan nanoparticles were achieved using the ionic gelation method and the in situ gel was prepared via a cold method. Developed CGNPs were characterized for particle size and zeta potential. Pluronic F127 was used as a gelling agent for dental therapy. Formulated in situ gel was evaluated for clarity, pH, gelation temperature, viscosity, spreadability, drug content, texture profile and stability. The antibacterial potential of CGNPs-gel was evaluated against isolated dental pathogens, in vitro. Results revealed that in situ gel exhibited promising antibacterial activity against dental pathogens viz. Acinetobacter junii and Bacillus species. The results of the in vitro release study indicated that in situ gel achieved superior sustained-release of gallic acid (84% up to 6 hours), so that the formulation could significantly increase gallic acid bioavailability in the periodontal cavity.In conclusion, the in situ gel formulation developed in this work has significant potential for dental applications.

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