Background:
Depression is associated with a decreased cardiorespiratory fitness, and physical activity [PA] levels, higher rates of obesity, and dysfunction in autonomic control of heart rate [HR]. However, these parameters were mostly recorded with indirect methods. Thus, the aim of the current study was to investigate the relationships between depression scores and objective measures of body fatness, autonomic indices (i.e. HRV and HRR), cardiorespiratory fitness and PA levels; and subsequently to present the best predictive models of depression scores for this population, based on these variables.
Methods:
Thirty-five non-exercising women (26–43 years; maximal oxygen consumption [VO
2
max] ~ 17.4–38.3 mL/kg/min) volunteered for participation in this study. All participants responded to the Beck Depression Inventory [DBI] and were evaluated for body mass index [BMI], percentage of body fat, sum of skinfolds, and VO
2
max. Subsequently, over four consecutive days, an orthostatic test and a submaximal exercise on a cycle ergometer were performed to record HRV and HRR, respectively. In addition, incidental PA was recorded during 5 consecutive days using accelerometers.
Results:
depression scores were related to VO
2
max (
r
= −0.446,
p
= 0.007) and the sum of skinfolds (
r
= 0.434,
p
= 0.009). Several stepwise multiple linear regression models were performed and only VO
2
max was revealed as an independent predictor of the Beck scores (ß = −0.446,
R
2
= 0.199,
p
= 0.007).
Conclusion:
The present study revealed that VO
2
max and the sum of skinfolds were moderately related to depression scores, while VO
2
max was the only independent predictor of depression scores in female workers.
Objetivo: A ideação suicida é a emergência psiquiátrica mais frequentemente encontrada no contexto emergencial. Entretanto, devido à complexa interação entre seus fatores de risco, desconforto do paciente em abordar a temática, individualidade clínica dos episódios e déficit de intervenções farmacológicas eficazes, são escassos os protocolos que forneçam algoritmos para o manejo da entidade. Apesar de recentemente ter sido demonstrada a eficácia do uso de Ketamina no manejo da depressão, pouco se sabe sobre sua eficácia no manejo da ideação suicida. Nesta revisão foram avaliados ensaios clínicos que versam sobre o uso da ketamina no tratamento agudo da ideação suicida associada ou não a transtornos depressivos, de forma a determinar se o uso do fármaco é seguro e eficaz no manejo dessa emergência psiquiátrica. Fontes de dados: Foram realizadas buscas nas bases de dados PubMed, SciELO, Web of Science, Bireme e Scopus com os termos MeSH “Ketamine” e “Suicide ideation”. Síntese dos dados: Após a seleção, sem limites temporais, de ensaios clínicos randomizados e exclusão das duplicatas, foram incluídos 10 estudos nesta revisão. Conclusões: Os trabalhos demonstraram que a Ketamina é um fármaco de ação rápida e possivelmente sustentada na ideação suicida, bem como de efeitos adversos leves e auto-limitados. Entretanto, tais resultados devem ser reproduzidos em um maior número de pacientes, principalmente no que diz respeito ao uso de doses de manutenção.
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