Orofacial Granulomatosis (OFG) is a rare clinicopathological entity characterized clinically by the presence of continuous enlargement of the soft tissues of the oral and maxillofacial region and histologically by non-caseating and non-necrotizing granulomatous inammation. The term 'orofacial granulomatosis' has been introduced to indicate the group of various disorders, involving Melkersson-Rosenthal syndrome and granulomatous cheilitis and has been noted to be associated with Sarcoidosis, Crohn's disease and infectious diseases such as Tuberculosis. But, various etiological agents such as food additives, dental materials and microbial agents have been recommended in the disease process. Treatment of orofacial granulomatosis is by corticosteroids but it's not so efcient. It is more important to nd the pathogen rst to specify the appropriate treatment line.

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BACKGROUNDAcute Kidney Injury (AKI) in intensive care unit (ICU) is very common. This study looked at the clinical profile of patients admitted in ICU with AKI. MATERIALS AND METHODSProspective observational study was done in an ICU of a tertiary care centre in Mangalore. Patients admitted to the ICU who were 18 years of age and had diagnosis of AKI by KDIGO criteria were included in the study. Data was collected and analysed. RESULTSTotal number of patients included in the study was 100. Diabetes mellitus was the most common comorbidity seen in 38% cases followed by Hypertension in 27%. The duration of ICU stay ranged from 4 days to 12 days. Sepsis was the most common cause of AKI (51%). Forty-five percent of patients required haemodialysis. CONCLUSIONSepsis was the most common aetiological factor responsible for AKI. Diabetes mellitus was found to be the most common co-morbid illness associated with development of acute kidney injury. Respiratory tract infection was found to be the most common diagnosis at admission among those with AKI. Most AKI in ICU have oliguria. Acute tubular necrosis was found to be the most common pathophysiological process responsible for AKI. Forty-five percent of ICU-AKI patients require RRT. SOFA score of ≥ 9 and increasing severity of AKI were associated with increased mortality and also poor rate of recovery from acute kidney injury and increase d mortality.