Natural products and their derivatives are known to be useful for treating numerous diseases since ancient times. Because of their high therapeutic potentials, the use of different medicinal plants is possible to treat varied inflammation‐mediated chronic diseases. Among natural products, phytosteroids have emerged as promising compounds mostly because they have diverse pharmacological activities. Currently, available medications exert numerous systemic toxicities, including hypertension, immune suppression, osteoporosis, and metabolic abnormalities. Thus, further research on phytosteroids to subside these complications is of significant importance. In this study, the information on phytosteroids, their types, and actions against inflammation, and allergic complications was collected by a systematic survey of literature on several scientific search engines. The literature review suggested that phytosteroids exhibit antiinflammatory action via different modes through transrepression or selective COX‐2 enzymes. Also, in silico ADMET analysis was carried out on available phytosteroids to uncover their pharmacokinetic properties. Our analysis has shown that eight compounds: withaferin A, stigmasterol, β‐sitosterol, guggulsterone, diosgenin, sarsasapogenin, physalin A, and dioscin, −isolated from medicinal plants show similar pharmacokinetic properties as compared to dexamethasone, commercially available glucocorticoid. These phytosteroids could be useful for the treatment of inflammatory diseases, such as rheumatoid arthritis, inflammatory bowel diseases, multiple sclerosis, asthma, and cardiovascular diseases. Thus, systematic research is required to explore potent phytosteroids with lesser side effects, which might substitute the current medications.

The spread of COVID-19 is posing significant challenges to the household (HH) waste management sectors putting waste personnel and concerned bodies under massive pressure. The chain of collection, segregation, recycling, and disposal of household generated wastes is interrupted. This study aimed to assess how the household waste management chain was disrupted by novel coronavirus in Nepal and find the perception of the people towards the existing household waste management system (HHWMS). A descriptive online survey was carried out among 512 people using a cross-sectional research design and data was collected through a self-administered questionnaire method. Both descriptive, as well as inferential tests, were conducted using SPSS software. The finding of this study showed that 62.3% of respondents were not satisfied with the present HHWMS. Furthermore, there was a significant association of the satisfaction level of household waste management during coronavirus outbreak with gender, waste volume change in lockdown, PPE for waste collectors, and education on waste handling techniques provided by the government sector at 5% level of significance (p < 0.05). Proper HH waste management has become a challenge, and to address this some innovative works such as awareness programs for people, health and hygiene related support to waste workers, and effective policy formulation and implementation should be done by the Government of Nepal.

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Plastic pollution in various forms has emerged as the most severe environmental threat. Small plastic chunks, such as microplastics and nanoplastics derived from primary and secondary sources, are a major concern worldwide due to their adverse effects on the environment and public health. Several years have been spent developing robust spectroscopic techniques that should be considered top-notch; however, researchers are still trying to find efficient and straightforward methods for the analysis of microplastics but have yet to develop a viable solution. Because of the small size of these degraded plastics, they have been found in various species, from human brains to blood and digestive systems. Several pollution-controlling methods have been tested in recent years, and these methods are prominent and need to be developed. Bacterial degradation, sunlight-driven photocatalyst, fuels, and biodegradable plastics could be game-changers in future research on plastic pollution control. However, recent fledgling steps in controlling methods appear insufficient due to widespread contamination. As a result, proper regulation of environmental microplastics is a significant challenge, and the most equitable way to manage plastic pollution. Therefore, this paper discusses the current state of microplastics, some novel and well-known identification techniques, strategies for overcoming microplastic effects, and needed solutions to mitigate this planetary pollution. This review article, we believe, will fill a void in the field of plastic identification and pollution mitigation research.

Water is a prime natural resource and precious national asset and one of the chief constituents of the environment. The chemical characteristics play a key role in terms of ecological and economic perspectives in the river water. The characterization and evaluation of river water quality in the Karmanasha River is necessary due to its immense importance in the livelihood of the people in the core urban areas of Kathmandu valley, Nepal. In this study, the surface water samples were collected from 16 sites with a 0.5 km interval to characterize and evaluate the water quality mainly from the perspective of its irrigational usage. The assessment was carried out by applying electrical conductivity (EC), sodium percentage (Na%), sodium adsorption ratio (SAR), permeability index (PI), Kelly’s ratio (KR), magnesium adsorption ratio (MAR), cation ratio of soil structural stability (CROSS), Wilcox diagram and water quality index (WQI) including the general hydrochemistry. The general hydrochemistry of river water indicates slightly alkaline in nature with mean pH value 8.07, and the dominance order of major ions follows the pattern of Ca2+>Mg2+>Na+>K+ for cations, and HCO3->Cl->NO3- for anions. Furthermore, the results revealed that the water is safe for irrigation purposes based on EC, Na%, SAR, KR, MAR, CROSS, and Wilcox diagram. The results also specified that no severe degradation in water, however, the low DO, and high BOD and COD values than that of the standard value prescribed by Nepal Drinking Water Quality Standard, signify the anthropogenic signature in the river water. This study provides the baseline information about the WQI and suitability of irrigation water quality, and further in-depth studies are required at spatiotemporal levels to get in-depth insights about the ecological health of the river.