A new method was developed for the determination of trifluoperazine hydrochloride (TFPH) at trace levels in pharmaceuticals. This method involved formation of a TFPH-Pt(IV) complex at a specific pH, and extraction of this complex into an organic solvent. Flame atomic absorption spectrometry was used to measure the absorbance of platinum in the complex, and indirectly determine the concentration of TFPH. Under the optimized conditions, the linear dynamic range, detection limit, relative standard deviation (n = 5), and the recoveries of the standard addition method were 2−60 µg mL −1 , 0.085 µg mL −1 , 1.58−2.03, and 102.24 ± 0.43, respectively. The proposed method was applied to the determination of TFPH in the drug Stelazine (5 mg of TFPH per tablet) by both direct and standard addition procedures and gave results of 4.89 and 4.88 mg of TFPH per tablet. This method was compared statistically with the determination of TFPH by UV-Vis spectroscopy, and the difference in the precision from these methods was insignificant at the 95% confidence level.

A sensitive and simple spectrophotometric method for the estimation of adrenaline (ADH) in either pure form or in pharmaceutical preparations. The method is based on the reaction of adrenaline with vanadium (V) in acidic solution to from the colored complex which absorb at  max = 488 nm. A graph of absorbance versus concentration shows that Beer , s low is obeyed over concentration range of (0.5-140) g adrenaline ml -1 with a molar absorpitivity of (2.015× 10 3 Lit. mol -1 .cm-1 ), a sandell sensitivity of ( 0.09 g.cm -2 ) ,LOD (0.46g.ml -1 ) , Recovery % (101.16 0.97) , E rel % (1.17 0.97) .The mole-ratio method (1:2) approved that ADH-V (V) as a structure of the complex. The optimum conditions for full colour development are described and the proposed method was satisfactorily applied for the determination of ADH in pharmaceutical preparations. The response surface method (RSM) was applied for optimization of experimental condition and data obtained were found similar.