An Indirect Atomic Absorption Spectrophotometric Determination of Trifluoperazine Hydrochloride in Pharmaceuticals

Abstract

A new method was developed for the determination of trifluoperazine hydrochloride (TFPH) at trace levels in pharmaceuticals. This method involved formation of a TFPH-Pt(IV) complex at a specific pH, and extraction of this complex into an organic solvent. Flame atomic absorption spectrometry was used to measure the absorbance of platinum in the complex, and indirectly determine the concentration of TFPH. Under the optimized conditions, the linear dynamic range, detection limit, relative standard deviation (n = 5), and the recoveries of the standard addition method were 2−60 µg mL −1 , 0.085 µg mL −1 , 1.58−2.03, and 102.24 ± 0.43, respectively. The proposed method was applied to the determination of TFPH in the drug Stelazine (5 mg of TFPH per tablet) by both direct and standard addition procedures and gave results of 4.89 and 4.88 mg of TFPH per tablet. This method was compared statistically with the determination of TFPH by UV-Vis spectroscopy, and the difference in the precision from these methods was insignificant at the 95% confidence level.

Trifluoperazine-Loaded Leciplexes as Potential Nasal Delivery Systems for treatment of depression

“…In this volume, the sink condition was maintained. At 0.25, 0.5, 1, 2, 3, 4, 5, and 6 h, samples were withdrawn and replaced with equal volumes of fresh media and tested spectrophotometrically at 307 nm [19] . The cumulative percent of TFP release was calculated.…”

Iron Determination in Multivitamin Tablets: Enhancing Military Nutritional Preparedness Based Linear Regression Method

“…In addition, differences in sensitivity levels can also be another cause. AAS has a better level of sensitivity compared to UV-Vis spectrophotometry (Qassim et al, 2011). Judging from the packaging of the blood booster tablets tested, it was written that the Fe level was 38 mg/capsule.…”

“…This value is not much different from the results of measuring iron levels using AAS to obtain iron levels at a volume of 0.5 mL obtained around 35.891 mg/capsule while for a volume of 1 mL around 26.53 mg/capsule. Quite different values were obtained when the measurement of levels was carried out using the UV-Vis spectrophotometry method (Qassim et al, 2011). With this method, the iron levels that were measured were quite different from the iron levels listed on the packaging.…”

Development of a new indirect method for the determination of Trifluuperazine HCl in pharmaceutical formulations.

“…[5][6][7][8][9][10] Ultraviolet spectrophotometric 11 . Also, other types of techniques have been used: indirect atomic absorption method 12 . Voltammetry method 13 , Potentiometric sensors 14 .…”