Prune belly syndrome is a rare congenital disorder of the urinary system, characterized by a triad of abnormalities. The aetiology is not known. Many infants are either stillborn or die within the first few weeks of life from severe lung or kidney problems, or a combination of congenital anomalies.
This study utilized sub-millimeter 3T gradient echo MRI of the brainstem ex vivo to obtain a magnetic susceptibility map (QSM). ROIs of both deep brain nuclei and myelinated fiber tracts were chosen and quantified from QSM obtained from MRI field. The ex vivo specimens were then stained with Luxol Fast Blue and the resultant absorbance of the ROIs were compared to QSM. A strong linear correlation was observed (R2 = 0.897, p = 0.0041).
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