AbstractThe objective of the present study was to develop and characterize nano-ethanolic liposomes (NEL) for transdermal delivery of ibuprofen (IBU). The NEL for transdermal delivery of IBU were prepared by thin film hydration technique and evaluated for vesicle size, shape, entrapment efficiency, transdermal flux, andin vivoanti-inflammatory activity in Wistar rats. The NEL optimized formulation (NEL-Opt) presented vesicle sizes of 32.85±1.98 nm and entrapment efficiency of 86.40±0.55% with improved transdermal flux. The presence of ethanol and flexibility of NEL could be the reasons for better permeation enhancement of IBU via rat’s skin.In vivoanti-inflammatory study of IBU-loaded NEL-Opt gel showed significant reduction (41.18%) of edema in carrageenan-induced rat paw edema as compared to conventional gel of IBU, where reduction of edema was found to be 12.50%. Our results suggest that developed NEL formulations are efficient systems for transdermal IBU delivery against inflammation. The stability study confirmed that the NEL-Opt gel formulation was considerably stable at refrigerator temperature. Our results concluded that NEL are an efficient carrier for transdermal delivery of IBU.

Aim: To develop and statistically optimize nanoethosomal formulation for transdermal delivery of vinpocetine as an anti-Alzheimer's drug. Materials and methods: Box-Behnken experimental design was applied for optimization of nanoethosomes. The independent variables were phospholipid (X 1 ), Tween 80 (X 2 ) and Ethanol (X 3 ) while entrapment efficiency (Y 1 ), particle sizes (Y 2 ), elasticity (Y 3 ) and flux (Y 4 ) were the dependent variables. Results and conclusion: Optimized nanoethosomal vinpocetine formulation with mean particle size 50.57 AE 26.11 nm showed 97.51 AE 0.86% entrapment efficiency, achieved mean transdermal flux 925.60 AE 39.80 mg/cm 2 /h and elasticity of 86.61 AE 2.88. Ex-vivo study of nanoethosomal formulation showed a significant increase flux and entrapment efficiency compared with control vinpocetine solution. Our results suggest that nanoethosome is an efficient carrier for transdermal delivery of vinpocetine as compared to its oral form.