Nanoethosomes mediated transdermal delivery of vinpocetine for management of Alzheimer’s disease

Abstract

Aim: To develop and statistically optimize nanoethosomal formulation for transdermal delivery of vinpocetine as an anti-Alzheimer's drug. Materials and methods: Box-Behnken experimental design was applied for optimization of nanoethosomes. The independent variables were phospholipid (X 1 ), Tween 80 (X 2 ) and Ethanol (X 3 ) while entrapment efficiency (Y 1 ), particle sizes (Y 2 ), elasticity (Y 3 ) and flux (Y 4 ) were the dependent variables. Results and conclusion: Optimized nanoethosomal vinpocetine formulation with mean particle size 50.57 AE 26.11 nm showed 97.51 AE 0.86% entrapment efficiency, achieved mean transdermal flux 925.60 AE 39.80 mg/cm 2 /h and elasticity of 86.61 AE 2.88. Ex-vivo study of nanoethosomal formulation showed a significant increase flux and entrapment efficiency compared with control vinpocetine solution. Our results suggest that nanoethosome is an efficient carrier for transdermal delivery of vinpocetine as compared to its oral form.

Current advances in transdermal delivery of drugs for alzheimer's disease

“…Compared to vinpocetine solution, the nanoethosomal form increased the flux and entrapment efficiency and has a potential for transdermal use in AD. [78]…”

First report on the electrooxidation of vinpocetine using a modification free sensing platform: application to pharmaceutical formulations

“…1,2 VIN is widely used to treat cerebrovascular and cognitive disorders. 3,4 Several analytical methods have been reported for quantifying VIN in different matrices (e.g., vinca extracts, pharmaceutical formulations, plasma, and urine). These methods include high-performance liquid chromatography, 5 gas chromatography, 6,7 and liquid chromatography, 8 which are considered highly sensitive strategies.…”

Formulation & Evaluation of Naringin Nanoethosome by Cold Method

“…Actual drug content[13,18] Precisely weighed equivalent quantity (10 mg) of nanoethosomes containing drug was kept in 100 ml of phosphate buffer pH 7.4 solutions for an hour with continuous stirring. Filtered samples were further analysed at 283 nm next to blank using UV-visible spectrophotometer (…”